Chemistry and bioactivity of an artificial adenosylpeptide B(12) cofactor

Artificial influence: We describe a semi-artificial adenosylpeptide B(12) that behaves as a cofactor in B(12)-dependent enzymatic reactions and demonstrate that the peptide backbone influences its chemical properties and modulates its bioactivity in vitro and in vivo. Inhibition of the growth of L....

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2012-09, Vol.13 (14), p.2052-2055
Hauptverfasser:	Zhou, Kai, Oetterli, René M, Brandl, Helmut, Lyatuu, Fredrick E, Buckel, Wolfgang, Zelder, Felix
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Biomimetic Materials - chemistry Biomimetic Materials - metabolism Clostridium - drug effects Clostridium - enzymology Coenzymes - chemistry Coenzymes - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Hydrogen-Ion Concentration Intramolecular Transferases - antagonists & inhibitors Intramolecular Transferases - metabolism Kinetics Lactobacillus delbrueckii - drug effects Peptides - chemistry Peptides - metabolism Temperature Vitamin B 12 - chemistry
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Zusammenfassung:	Artificial influence: We describe a semi-artificial adenosylpeptide B(12) that behaves as a cofactor in B(12)-dependent enzymatic reactions and demonstrate that the peptide backbone influences its chemical properties and modulates its bioactivity in vitro and in vivo. Inhibition of the growth of L. delbrueckii is demonstrated, thus providing a potentially powerful approach for the development of antibacterial and antiproliferative compounds.
ISSN:	1439-7633
DOI:	10.1002/cbic.201200429