Metabolic syndrome, mild cognitive impairment and Alzheimer's disease—The emerging role of systemic low-grade inflammation and adiposity

Highlights ► Metabolic syndrome serves as a risk factor for Alzheimer's disease. ► Adipose-derived hormones and pro-inflammatory signals contribute to neurodegeneration. ► The role of leptin and adiponectin remains unclear. ► Presented findings indicate the impact of several unexplored adipokin...

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Veröffentlicht in:	Brain research bulletin 2012-11, Vol.89 (3), p.144-149
Hauptverfasser:	Misiak, Blazej, Leszek, Jerzy, Kiejna, Andrzej
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiposity Alzheimer Disease - epidemiology Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Protein Precursor - metabolism Animals Cognitive Dysfunction - epidemiology Cognitive Dysfunction - pathology Cytokines - metabolism Humans Inflammation Inflammation - etiology Metabolic Diseases - epidemiology Metabolic Diseases - pathology Metabolic syndrome Mild cognitive impairment Neurology
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Zusammenfassung:	Highlights ► Metabolic syndrome serves as a risk factor for Alzheimer's disease. ► Adipose-derived hormones and pro-inflammatory signals contribute to neurodegeneration. ► The role of leptin and adiponectin remains unclear. ► Presented findings indicate the impact of several unexplored adipokines.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2012.08.003