Synthesis and Pharmacological Profile of a New Selective G Protein-Coupled Receptor 119 Agonist; 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one

6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one is a potent drug-like G protein-coupled receptor 119 (GPR119) agonist. It is hoped that this compound would be instrumental in probing the pharmacological potential of GPR119 agonists.

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2012/09/01, Vol.60(9), pp.1093-1095
Hauptverfasser:	Sakairi, Masao, Kogami, Masakazu, Torii, Masafumi, Makino, Mitsuhiro, Kataoka, Daisuke, Okamoto, Ryuji, Miyazawa, Toshiyuki, Inoue, Megumi, Takahashi, Naoki, Harada, Satoko, Watanabe, Nobuhide
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line G protein-coupled receptor 119 agonist gastric emptying glucagon-like peptide-1 Glucose Tolerance Test glucose-dependent insulin secretagogue Humans Indenes - chemical synthesis Indenes - chemistry Indenes - pharmacokinetics Indenes - pharmacology Male Mice Mice, Inbred C57BL Piperidines - chemical synthesis Piperidines - chemistry Piperidines - pharmacokinetics Piperidines - pharmacology Rats Rats, Wistar Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism
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Beschreibung
Zusammenfassung:	6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one is a potent drug-like G protein-coupled receptor 119 (GPR119) agonist. It is hoped that this compound would be instrumental in probing the pharmacological potential of GPR119 agonists.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c12-00484