Tetrapeptide H-Ala-Glu-Asp-Arg-OH Stimulates Expression of Cytoskeletal and Nuclear Matrix Proteins

Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2012-08, Vol.153 (4), p.559-562
Hauptverfasser:	Khavinson, V. Kh, Lin’kova, N. S., Polyakova, V. O., Kvetnoy, I. M., Benberin, V. V., D’yakonov, M. M., Titkov, Yu. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Cell Biology Cell Proliferation - drug effects Cells, Cultured Cytoskeletal Proteins - metabolism Fibroblasts Gene Expression Regulation - drug effects Image Processing, Computer-Assisted Intermediate filament proteins Internal Medicine Laboratory Medicine Lamin Type A - genetics Mice Mice, Knockout Microscopy, Fluorescence Nuclear Matrix-Associated Proteins - metabolism Oligopeptides - pharmacology Pathology Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Tubulins
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Zusammenfassung:	Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by its capacity to activate synthesis of cytoskeletal and nuclear matrix proteins, which stimulates cell proliferation and reduces apoptosis.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-012-1766-9