An alternative one-pot gold-catalyzed approach to the assembly of 11H-indolo[3,2-c]quinolines

An alternative one-pot gold-catalyzed approach to the assembly of 11H-indolo[3,2-c]quinolines

A new one-pot approach was developed to construct the 11H-indolo[3,2-c]quinoline scaffold through a gold-catalysed reaction of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aldehydes. The broad scope and the high regioselectivity of this new protocol as well as the mild and neutral reaction...

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Veröffentlicht in:Organic & biomolecular chemistry 2012-10, Vol.10 (38), p.7801-7808
Hauptverfasser: Abbiati, Giorgio, Arcadi, Antonio, Chiarini, Marco, Marinelli, Fabio, Pietropaolo, Emanuela, Rossi, Elisabetta
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Gold - chemistry
Indoles - chemical synthesis
Indoles - chemistry
Molecular Structure
Organogold Compounds - chemistry
Quinolines - chemical synthesis
Quinolines - chemistry
Stereoisomerism
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Zusammenfassung:A new one-pot approach was developed to construct the 11H-indolo[3,2-c]quinoline scaffold through a gold-catalysed reaction of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aldehydes. The broad scope and the high regioselectivity of this new protocol as well as the mild and neutral reaction conditions make it a viable alternative to the previously reported procedures.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob26380g