Serial and panel analyses of biomarkers do not improve the prediction of bacteremia compared to one procalcitonin measurement

Summary Objectives We evaluated the value of a single biomarker, biomarker panels, biomarkers combined with clinical signs of sepsis, and serial determinations of biomarkers in the prediction of bacteremia in patients with sepsis. Methods Adult patients visiting the emergency department because of a suspected infection with at least two of the following symptoms: temperature >38.3 °C or 90/min, respiratory rate >20/min, chills, altered mental status, systolic blood pressure