Inflammatory and thrombotic changes in early bereavement: a prospective evaluation
Aims: Although there is an increased cardiovascular risk in the immediate weeks following bereavement, the mechanism is not well understood. The aim of this study was to determine whether inflammatory and thrombotic changes were present in acute bereavement. Methods and results: Eighty bereaved spou...
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| Veröffentlicht in: | European journal of preventive cardiology 2012-10, Vol.19 (5), p.1145-1152 |
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| container_title | European journal of preventive cardiology |
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| creator | Buckley, Thomas Morel-Kopp, Marie-Christine Ward, Christopher Bartrop, Roger McKinley, Sharon Mihailidou, Anastasia Susie Spinaze, Monica Chen, Walter Tofler, Geoffrey |
| description | Aims: Although there is an increased cardiovascular risk in the immediate weeks following bereavement, the mechanism is not well understood. The aim of this study was to determine whether inflammatory and thrombotic changes were present in acute bereavement.
Methods and results: Eighty bereaved spouses or parents were prospectively studied within 2 weeks of bereavement (acute) and at 6 months, and compared to 80 non-bereaved participants. Haemostatic measures were obtained between 8 a.m. and 11 a.m. and processed within 1 h. Compared to non-bereaved participants, those acutely bereaved had a higher neutrophil count (4.34 ± 0.19 vs 3.79 ± 0.15, p = |
| doi_str_mv | 10.1177/1741826711421686 |
| format | Article |
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Methods and results: Eighty bereaved spouses or parents were prospectively studied within 2 weeks of bereavement (acute) and at 6 months, and compared to 80 non-bereaved participants. Haemostatic measures were obtained between 8 a.m. and 11 a.m. and processed within 1 h. Compared to non-bereaved participants, those acutely bereaved had a higher neutrophil count (4.34 ± 0.19 vs 3.79 ± 0.15, p = <0.001), von Willebrand factor antigen (132.33 ± 3.6 vs 119.95 ± 3.29, p = 0.02), Factor VIII (1.43 ± 0.06 vs 1.25 ± 0.04, p = 0.02) and platelet/granulocyte aggregates (median 383.0 vs 343.5, p = 0.02). Levels of neutrophils, monocytes, eosinophils, platelet count, platelet/monocyte granulocytes and von Willebrand factor were lower in bereaved at 6 months compared to acutely (all p < 0.05).
Conclusion: Acute bereavement is associated with inflammatory and prothrombotic changes that may contribute to the increased cardiovascular risk with bereavement and provide clues for future preventative strategies.</description><identifier>ISSN: 2047-4873</identifier><identifier>EISSN: 2047-4881</identifier><identifier>DOI: 10.1177/1741826711421686</identifier><identifier>PMID: 21900365</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bereavement ; Female ; Follow-Up Studies ; Hemostasis - physiology ; Humans ; Incidence ; Inflammation - blood ; Inflammation - epidemiology ; Inflammation - psychology ; Male ; Middle Aged ; New South Wales - epidemiology ; Parents - psychology ; Prospective Studies ; Risk Assessment ; Risk Factors ; Spouses - psychology ; Thrombosis - blood ; Thrombosis - epidemiology ; Thrombosis - psychology</subject><ispartof>European journal of preventive cardiology, 2012-10, Vol.19 (5), p.1145-1152</ispartof><rights>The European Society of Cardiology 2011 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-585f92d6a0d91c6fa6fb3736075fddd37d9b75b6c9eaaa4254605d4db358e9c73</citedby><cites>FETCH-LOGICAL-c445t-585f92d6a0d91c6fa6fb3736075fddd37d9b75b6c9eaaa4254605d4db358e9c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1741826711421686$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1741826711421686$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21900365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buckley, Thomas</creatorcontrib><creatorcontrib>Morel-Kopp, Marie-Christine</creatorcontrib><creatorcontrib>Ward, Christopher</creatorcontrib><creatorcontrib>Bartrop, Roger</creatorcontrib><creatorcontrib>McKinley, Sharon</creatorcontrib><creatorcontrib>Mihailidou, Anastasia Susie</creatorcontrib><creatorcontrib>Spinaze, Monica</creatorcontrib><creatorcontrib>Chen, Walter</creatorcontrib><creatorcontrib>Tofler, Geoffrey</creatorcontrib><title>Inflammatory and thrombotic changes in early bereavement: a prospective evaluation</title><title>European journal of preventive cardiology</title><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><description>Aims: Although there is an increased cardiovascular risk in the immediate weeks following bereavement, the mechanism is not well understood. The aim of this study was to determine whether inflammatory and thrombotic changes were present in acute bereavement.
Methods and results: Eighty bereaved spouses or parents were prospectively studied within 2 weeks of bereavement (acute) and at 6 months, and compared to 80 non-bereaved participants. Haemostatic measures were obtained between 8 a.m. and 11 a.m. and processed within 1 h. Compared to non-bereaved participants, those acutely bereaved had a higher neutrophil count (4.34 ± 0.19 vs 3.79 ± 0.15, p = <0.001), von Willebrand factor antigen (132.33 ± 3.6 vs 119.95 ± 3.29, p = 0.02), Factor VIII (1.43 ± 0.06 vs 1.25 ± 0.04, p = 0.02) and platelet/granulocyte aggregates (median 383.0 vs 343.5, p = 0.02). Levels of neutrophils, monocytes, eosinophils, platelet count, platelet/monocyte granulocytes and von Willebrand factor were lower in bereaved at 6 months compared to acutely (all p < 0.05).
Conclusion: Acute bereavement is associated with inflammatory and prothrombotic changes that may contribute to the increased cardiovascular risk with bereavement and provide clues for future preventative strategies.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bereavement</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hemostasis - physiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Inflammation - blood</subject><subject>Inflammation - epidemiology</subject><subject>Inflammation - psychology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>New South Wales - epidemiology</subject><subject>Parents - psychology</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Spouses - psychology</subject><subject>Thrombosis - blood</subject><subject>Thrombosis - epidemiology</subject><subject>Thrombosis - psychology</subject><issn>2047-4873</issn><issn>2047-4881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1Lw0AQxRdRbKm9e5I9eonuZr8Sb1L8KBQE0XOY7E5qJB91Nyn0v3eltQfBucwcfu_x5hFyydkN58bcciN5lmrDuUy5zvQJmaZMmkRmGT893kZMyDyETxZHszTNsnMySXnOmNBqSl6XXdVA28LQ-x2FztHhw_dt2Q-1pfYDujUGWncUwTc7WqJH2GKL3XBHgW58HzZoh3qLFLfQjDDUfXdBzipoAs4Pe0beHx_eFs_J6uVpubhfJVZKNSQqU1WeOg3M5dzqCnRVCiM0M6pyzgnj8tKoUtscAUCmSmqmnHSlUBnm1ogZud77xhhfI4ahaOtgsWmgw34MBWciZyIWoCPK9qiNiYPHqtj4ugW_i1DxU2bxt8wouTq4j2WL7ij4rS4CyR4IsMbisx99F7_93_AbUeZ8bw</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Buckley, Thomas</creator><creator>Morel-Kopp, Marie-Christine</creator><creator>Ward, Christopher</creator><creator>Bartrop, Roger</creator><creator>McKinley, Sharon</creator><creator>Mihailidou, Anastasia Susie</creator><creator>Spinaze, Monica</creator><creator>Chen, Walter</creator><creator>Tofler, Geoffrey</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Inflammatory and thrombotic changes in early bereavement: a prospective evaluation</title><author>Buckley, Thomas ; Morel-Kopp, Marie-Christine ; Ward, Christopher ; Bartrop, Roger ; McKinley, Sharon ; Mihailidou, Anastasia Susie ; Spinaze, Monica ; Chen, Walter ; Tofler, Geoffrey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-585f92d6a0d91c6fa6fb3736075fddd37d9b75b6c9eaaa4254605d4db358e9c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bereavement</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hemostasis - physiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Inflammation - blood</topic><topic>Inflammation - epidemiology</topic><topic>Inflammation - psychology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>New South Wales - epidemiology</topic><topic>Parents - psychology</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Spouses - psychology</topic><topic>Thrombosis - blood</topic><topic>Thrombosis - epidemiology</topic><topic>Thrombosis - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buckley, Thomas</creatorcontrib><creatorcontrib>Morel-Kopp, Marie-Christine</creatorcontrib><creatorcontrib>Ward, Christopher</creatorcontrib><creatorcontrib>Bartrop, Roger</creatorcontrib><creatorcontrib>McKinley, Sharon</creatorcontrib><creatorcontrib>Mihailidou, Anastasia Susie</creatorcontrib><creatorcontrib>Spinaze, Monica</creatorcontrib><creatorcontrib>Chen, Walter</creatorcontrib><creatorcontrib>Tofler, Geoffrey</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of preventive cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buckley, Thomas</au><au>Morel-Kopp, Marie-Christine</au><au>Ward, Christopher</au><au>Bartrop, Roger</au><au>McKinley, Sharon</au><au>Mihailidou, Anastasia Susie</au><au>Spinaze, Monica</au><au>Chen, Walter</au><au>Tofler, Geoffrey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory and thrombotic changes in early bereavement: a prospective evaluation</atitle><jtitle>European journal of preventive cardiology</jtitle><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>19</volume><issue>5</issue><spage>1145</spage><epage>1152</epage><pages>1145-1152</pages><issn>2047-4873</issn><eissn>2047-4881</eissn><abstract>Aims: Although there is an increased cardiovascular risk in the immediate weeks following bereavement, the mechanism is not well understood. The aim of this study was to determine whether inflammatory and thrombotic changes were present in acute bereavement.
Methods and results: Eighty bereaved spouses or parents were prospectively studied within 2 weeks of bereavement (acute) and at 6 months, and compared to 80 non-bereaved participants. Haemostatic measures were obtained between 8 a.m. and 11 a.m. and processed within 1 h. Compared to non-bereaved participants, those acutely bereaved had a higher neutrophil count (4.34 ± 0.19 vs 3.79 ± 0.15, p = <0.001), von Willebrand factor antigen (132.33 ± 3.6 vs 119.95 ± 3.29, p = 0.02), Factor VIII (1.43 ± 0.06 vs 1.25 ± 0.04, p = 0.02) and platelet/granulocyte aggregates (median 383.0 vs 343.5, p = 0.02). Levels of neutrophils, monocytes, eosinophils, platelet count, platelet/monocyte granulocytes and von Willebrand factor were lower in bereaved at 6 months compared to acutely (all p < 0.05).
Conclusion: Acute bereavement is associated with inflammatory and prothrombotic changes that may contribute to the increased cardiovascular risk with bereavement and provide clues for future preventative strategies.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21900365</pmid><doi>10.1177/1741826711421686</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; SAGE Complete; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Bereavement Female Follow-Up Studies Hemostasis - physiology Humans Incidence Inflammation - blood Inflammation - epidemiology Inflammation - psychology Male Middle Aged New South Wales - epidemiology Parents - psychology Prospective Studies Risk Assessment Risk Factors Spouses - psychology Thrombosis - blood Thrombosis - epidemiology Thrombosis - psychology |
| title | Inflammatory and thrombotic changes in early bereavement: a prospective evaluation |
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