Dermal absorption of amorphous nanosilica particles after topical exposure for three days

The skin penetration and cellular localization of welldispersed amorphous nanosilica particles (nSPs) with a diameter of 70 nm was analyzed in mice. Our results suggest that after topical exposure for three days the particles penetrate the skin barrier and are transported to the lymph nodes. These f...

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Veröffentlicht in:	Pharmazie 2012-08, Vol.67 (8), p.742-743
Hauptverfasser:	Hirai, T, Yoshikawa, T, Nabeshi, H, Yoshida, T, Akase, T, Yoshioka, Y, Itoh, N, Tsutsumi, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Administration, Topical Animals Ear, External - metabolism Mice Mice, Inbred BALB C Microscopy, Electron, Transmission Nanoparticles - administration & dosage Silicon Dioxide - administration & dosage Silicon Dioxide - pharmacokinetics Skin Absorption - physiology Suspensions
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Beschreibung
Zusammenfassung:	The skin penetration and cellular localization of welldispersed amorphous nanosilica particles (nSPs) with a diameter of 70 nm was analyzed in mice. Our results suggest that after topical exposure for three days the particles penetrate the skin barrier and are transported to the lymph nodes. These findings underscore the need to examine biological effects following dermal exposure to nSPs for the development of safer use of nSPs.
ISSN:	0031-7144
DOI:	10.1691/ph.2012.1853