Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types

The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requ...

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Veröffentlicht in:	Cell stem cell 2012-08, Vol.11 (2), p.147-152
Hauptverfasser:	Taylor, Craig J., Peacock, Sarah, Chaudhry, Afzal N., Bradley, J. Andrew, Bolton, Eleanor M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Donors Fundamental and applied biological sciences. Psychology Graft rejection Histocompatibility antigen HLA Histocompatibility Testing HLA Antigens - immunology Humans Immunosuppression Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - immunology Inhibitory postsynaptic potentials Molecular and cellular biology Stem Cell Transplantation - methods Stem cells Tissue Donors Tissue typing Transplantation, Homologous
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Beschreibung
Zusammenfassung:	The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.
ISSN:	1934-5909 1875-9777
DOI:	10.1016/j.stem.2012.07.014