Genomic structure, molecular characterization and functional analysis of Pekin duck interleukin-10

► This study is the first characterization of interleukin (IL)-10 in the Pekin duck. ► The duck IL-10 gene has an alternative exon. ► It gives rise to two novel alternatively spliced IL-10 transcripts. ► IL-10 transcripts were most abundant in lung, bursa, cecal tonsils, spleen and liver. ► Bioactiv...

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Veröffentlicht in:	Developmental and comparative immunology 2012-09, Vol.38 (1), p.30-43
Hauptverfasser:	Yao, Qingxia, Fischer, Karl P., Lorne Tyrrell, D., Gutfreund, Klaus S.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' untranslated regions Alternative exon Alternative Splicing Amino acids Animals Base Sequence C-Terminus chickens Comparative immunology ducks Ducks - genetics Ducks - immunology evolution Evolutionary conservation Exons genes Genomic organization genomics Homology Humans Immune response Immunity Interleukin 10 Interleukin 2 Interleukin-10 - chemistry Interleukin-10 - genetics Interleukin-10 - immunology Introns Lung Models, Molecular Molecular Sequence Data Monomers mononuclear leukocytes Pekin Pekin duck Phylogeny Sequence Alignment Splenocytes Splice variants Structure-function relationships
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