An aptazyme-based molecular device that converts a small-molecule input into an RNA output

We describe the construction of an aptazyme-based molecular device that converts, through a cascade of reactions, a small-molecule input into output RNA strands. This device is applicable as an interface between a small molecule and a molecular system that accepts only nucleic acid input.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2012-08, Vol.48 (61), p.7556-7558
Hauptverfasser:	Ayukawa, Shotaro, Sakai, Yoko, Kiga, Daisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - metabolism Biosensing Techniques - methods Chemical communication DNA, Catalytic - metabolism Flavin Mononucleotide - metabolism RNA - analysis RNA - metabolism RNA, Catalytic - metabolism
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Beschreibung
Zusammenfassung:	We describe the construction of an aptazyme-based molecular device that converts, through a cascade of reactions, a small-molecule input into output RNA strands. This device is applicable as an interface between a small molecule and a molecular system that accepts only nucleic acid input.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c2cc31886e