Magnetic response of mitochondria-targeted cancer cells with bacterial magnetic nanoparticles

We first demonstrate the effects of magnetic trapping of mitochondria using aptamer conjugated to bacterial magnetic nanoparticles that allowed targeting of the mitochondrial cytochrome c in the treatment of cancer cells. Our findings offer a new approach for targeted cell therapy, with the advantag...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2012-08, Vol.48 (60), p.7474-7476
Hauptverfasser:	Choi, Jungin, Shin, Jaeha, Lee, Junghoon, Cha, Misun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers Aptamers, Nucleotide - administration & dosage Aptamers, Nucleotide - pharmacology Bacteria Cell Death Cytochromes c - metabolism HeLa Cells Humans Magnetic Fields Magnetosomes - metabolism Magnetosomes - ultrastructure Magnetospirillum - ultrastructure Mitochondria - metabolism Neoplasms - metabolism Neoplasms - therapy
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Beschreibung
Zusammenfassung:	We first demonstrate the effects of magnetic trapping of mitochondria using aptamer conjugated to bacterial magnetic nanoparticles that allowed targeting of the mitochondrial cytochrome c in the treatment of cancer cells. Our findings offer a new approach for targeted cell therapy, with the advantage of remote control over subcellular elements.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c2cc33659f