Predictive Value of Left Ventricular Remodeling by Area Strain Based on Three-Dimensional Wall-Motion Tracking After PCI in Patients with Recent NSTEMI

Abstract We aimed to explore whether a novel left ventricular performance index, area strain (AS), based on three-dimensional wall-motion tracking (3-D-WMT) done before and after percutaneous coronary intervention (PCI) could predict left ventricular (LV) remodeling in patients with recent non-ST el...

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Veröffentlicht in:Ultrasound in medicine & biology 2012-09, Vol.38 (9), p.1491-1501
Hauptverfasser: Li, Xiu-Chang, Jin, Feng-Lin, Jing, Cai, Xiao, Qiang, Liu, Yan, Ran, Zhang-Shen, Zhang, Jia-Jun
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Sprache:eng
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Zusammenfassung:Abstract We aimed to explore whether a novel left ventricular performance index, area strain (AS), based on three-dimensional wall-motion tracking (3-D-WMT) done before and after percutaneous coronary intervention (PCI) could predict left ventricular (LV) remodeling in patients with recent non-ST elevation myocardial infarction (NSTEMI). Sixty-one patients (53.6 ± 8.8 years) with recent NSTEMI were enrolled. Coronary angiography and PCI were undertaken for reperfusion. Parameters of myocardial deformation (including LV end-diastolic volume, LV end-systolic volume, LV ejection fraction, LV global and regional peak area strain) were measured by 3-D-WMT before and 1 week after reperfusion therapy. Six months after reperfusion, LV negative remodeling was defined as lack of improvement in LV function, with increase in LV end-diastolic volume ≥15%. Patients were subdivided into remodeled group (n = 25) and non-remodeled group (n = 36) at follow-up. Patients with negative LV remodeling had significantly higher cardiac troponin I (cTnI) levels at baseline (21.21 ± 12.22 vs. 15.56 ± 8.91 ng/mL; p  = 0.0357), higher B-type natriuretic peptide (BNP) level (247.56 ± 177.39 vs. 170.53 ± 97.89 pg/mL; p  = 0.0336) and reduced global AS (−27.9 ± 4.6% vs. −31.9 ± 4.3%; p  = 0.001) than those without remodeling. Global AS at baseline had a significantly close correlation with cTnI level 36 h after MI (r = 0.71, p  
ISSN:0301-5629
1879-291X
DOI:10.1016/j.ultrasmedbio.2012.05.006