Parthenolide Inhibits the LPS-induced Secretion of IL-6 and TNF-α and NF-κB Nuclear Translocation in BV-2 Microglia

Feverfew (Tanacetum parthenium [L.] Sch. Bip. [Asteraceae]) is a popular herbal treatment used to prevent and treat headache and migraine. Parthenolide (PTN), the sesquiterpene lactonic derivative that is the plant's major component, might be one of the ingredients that act on mediators of infl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Phytotherapy research 2012-09, Vol.26 (9), p.1405-1409
Hauptverfasser:	Magni, Paolo, Ruscica, Massimiliano, Dozio, Elena, Rizzi, Eleonora, Beretta, Giangiacomo, Facino, Roberto Maffei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line General pharmacology IL-6 inflammation Interleukin-6 - secretion Lipopolysaccharides Medical sciences Mice microglia Microglia - drug effects Microglia - metabolism migraine NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-κB parthenolide Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Protein Transport Sesquiterpenes - pharmacology Tanacetum parthenium Tanacetum parthenium - chemistry TNF-α Tumor Necrosis Factor-alpha - secretion
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Feverfew (Tanacetum parthenium [L.] Sch. Bip. [Asteraceae]) is a popular herbal treatment used to prevent and treat headache and migraine. Parthenolide (PTN), the sesquiterpene lactonic derivative that is the plant's major component, might be one of the ingredients that act on mediators of inflammation. In the present study, in cultured lipopolysaccharide (LPS)‐stimulated BV‐2 microglia pretreatment with PTN caused a dose‐dependent reduction of interleukin‐6 (IL‐6) secretion (29% by 200 nm, p
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.3732