Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles

An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for their antibacterial, anti-inflammatory and cytotox...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-08, Vol.22 (16), p.5272-5278
Hauptverfasser:	Mandha, Santhosh Reddy, Siliveri, Sravanthi, Alla, Manjula, Bommena, Vittal Rao, Bommineni, Madhava Reddy, Balasubramanian, Sridhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-inflammatory activity Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents - toxicity Antibacterial activity Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cell Proliferation - drug effects chemistry Crystallography, X-Ray Cytotoxic activity Cytotoxicity Edema - chemically induced Edema - drug therapy Ethanol Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Humans Inflammation MCF-7 Cells Medical sciences Microbial Sensitivity Tests Molecular Conformation Multicomponent reactions Non-catalytic conditions Pharmacology. Drug treatments pyrazoles Pyrazoles - chemistry Pyrazoles - therapeutic use Pyrazoles - toxicity Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for their antibacterial, anti-inflammatory and cytotoxic activities.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2012.06.055