Asymmetric Transfer Hydrogenation of Ketimines Using Well-Defined Iron(II)-Based Precatalysts Containing a PNNP Ligand

Asymmetric Transfer Hydrogenation of Ketimines Using Well-Defined Iron(II)-Based Precatalysts Containing a PNNP Ligand

Well-defined iron(II)-based complexes containing PNNP ligands catalyze a highly enantioselective reduction of N-(diphenylphosphinoyl)- and N-(p-tolylsulphonyl)-ketimines. Under mild conditions and low catalyst loading, the ketimines are successfully reduced to the corresponding amines in enantiomeri...

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Veröffentlicht in:Organic letters 2012-09, Vol.14 (17), p.4638-4641
Hauptverfasser: Mikhailine, Alexandre A, Maishan, Mazharul I, Morris, Robert H
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Ferrous Compounds - chemistry
Hydrogenation
Imines - chemistry
Ligands
Molecular Structure
Nitriles - chemistry
Phosphines - chemistry
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Zusammenfassung:Well-defined iron(II)-based complexes containing PNNP ligands catalyze a highly enantioselective reduction of N-(diphenylphosphinoyl)- and N-(p-tolylsulphonyl)-ketimines. Under mild conditions and low catalyst loading, the ketimines are successfully reduced to the corresponding amines in enantiomeric excess ranging from 94 to 99%.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol302079q