Fluorescence sensing of caffeine in aqueous solution with carbazole-based probe and imaging application in live cells

The host–guest interaction of caffeine in aqueous solutions has been achieved by using carbazole based imino-phenol receptors with oxopurines influences their fluorescence properties and can be exploited for ‘turn-ON’ fluorescence sensing of caffeine. This new fluorescent probe with high sensitivity...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-09, Vol.22 (17), p.5379-5383
Hauptverfasser:	Mahapatra, Ajit Kumar, Roy, Jagannath, Sahoo, Prithidipa, Mukhopadhyay, Subhra Kanti, Mukhopadhyay, Anindita Roy, Mandal, Debasish
Format:	Artikel
Sprache:	eng
Schlagworte:	aqueous solutions Biological and medical sciences Caffeine Caffeine - analysis Candida albicans Candida albicans - cytology Carbazole Carbazoles - chemistry Cell Survival Computed tomography Fluorescence Fluorescent Dyes - chemistry Fluorescent indicators image analysis Medical sciences Microscopy, Fluorescence - methods Models, Molecular Pharmacology. Drug treatments Receptor mechanisms receptors Sensitivity and Specificity Spectrometry, Fluorescence - methods Water - chemistry Xanthine alkaloid ‘Turn-ON’ fluorescent probe
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Beschreibung
Zusammenfassung:	The host–guest interaction of caffeine in aqueous solutions has been achieved by using carbazole based imino-phenol receptors with oxopurines influences their fluorescence properties and can be exploited for ‘turn-ON’ fluorescence sensing of caffeine. This new fluorescent probe with high sensitivity and selectivity for detection and first time imaging of caffeine in living cells was developed in aqueous media.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2012.07.055