Unravelling fungal immunity through primary immune deficiencies

Highlights ► Patients with primary immune deficiencies have contributed enormously to our understanding of immunological pathways mediating immunity to fungi. ► Defects in PID patients demonstrate that mutually exclusive pathways underlie immunity to different types of fungal pathogens and infection...

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Veröffentlicht in:	Current opinion in microbiology 2012-08, Vol.15 (4), p.420-426
1. Verfasser:	Lilic, Desa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Antibodies Aspergillus Biological and medical sciences Candida candidiasis Chronic infection Chronic mucocutaneous candidiasis Cytokines - immunology Fundamental and applied biological sciences. Psychology Fungi Fungi - immunology Humans Immune system Immunity Immunity, Innate Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - microbiology Interleukin 1 Interleukin 17 Microbiology Mycoses - immunology Neutropenia Pathology patient care patients Phagocytes Reviews risk Stat1 protein Stat3 protein Th17 Cells - immunology Th17 Cells - microbiology
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Beschreibung
Zusammenfassung:	Highlights ► Patients with primary immune deficiencies have contributed enormously to our understanding of immunological pathways mediating immunity to fungi. ► Defects in PID patients demonstrate that mutually exclusive pathways underlie immunity to different types of fungal pathogens and infections. ► Immunity to mucocutaneous infection is critically dependent on Th-17 responses while phagocytes confer protection against invasive disease.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2012.06.003