Enantioselective aza-Henry reactions of cyclic α-carbonyl ketimines under bifunctional catalysis

Enantioselective aza-Henry reactions of cyclic α-carbonyl ketimines under bifunctional catalysis

The aza-Henry reaction of nitroalkanes with the C=N group of 2-aryl-3H-indol-3-ones catalyzed by thiourea-chincona derivatives takes place with good yield and high ee's.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-10, Vol.48 (78), p.9759-9761
Hauptverfasser: Parra, Alejandro, Alfaro, Ricardo, Marzo, Leyre, Moreno-Carrasco, Alberto, García Ruano, José Luis, Alemán, José
Format: Artikel
Sprache:eng
Schlagworte:
Alkanes - chemical synthesis
Alkanes - chemistry
Catalysis
Imines - chemistry
Indoles - chemistry
Molecular Structure
Nitriles - chemistry
Nitro Compounds - chemical synthesis
Nitro Compounds - chemistry
Stereoisomerism
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Zusammenfassung:The aza-Henry reaction of nitroalkanes with the C=N group of 2-aryl-3H-indol-3-ones catalyzed by thiourea-chincona derivatives takes place with good yield and high ee's.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc34053d