Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2'-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component

Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2'-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component

We describe a method to predict the stability of a modified RNA duplex. Ten unique modified RNA duplexes showed a linear relationship between the calculated and experimentally determined duplex stabilities.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-07, Vol.48 (58), p.7313-7315
Hauptverfasser: Masaki, Yoshiaki, Miyasaka, Ryuta, Hirai, Kunihiro, Tsunoda, Hirosuke, Ohkubo, Akihiro, Seio, Kohji, Sekine, Mitsuo
Format: Artikel
Sprache:eng
Schlagworte:
Chemical communication
Nucleic Acid Conformation
Oligoribonucleotides - chemistry
RNA - chemistry
RNA Stability
Thiouridine - analogs & derivatives
Thiouridine - chemistry
Transition Temperature
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Beschreibung
Zusammenfassung:We describe a method to predict the stability of a modified RNA duplex. Ten unique modified RNA duplexes showed a linear relationship between the calculated and experimentally determined duplex stabilities.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc33409g