Detection of aprepitant drug based on low-dimensional un-doped iron oxide nanoparticles prepared by a solution method

Un-doped low-dimensional iron oxide nanoparticles prepared with reducing agents by a solution method are used, which is a promising component in an extensive and wide-range of biomedical applications due to their novel characteristics and attractive properties. It is characterized by UV/visible, Raman, FT-IR spectroscopy's, powder X-ray diffraction, EDS, and FE-SEM and applied for the fabrication of highly sensitive aprepitant drug sensor in short response time. The analytical performances of APPT sensors with large-active surface area of NPs/GCE have higher sensitivity, lower detection limit, long-term stability, and exhibit highly enhanced APPT drug detection in simple and reliable I–V method. This method could also be employed for the determination of drugs in quality control of formulation using a reliable I–V method. [Display omitted] ► Detection of Aprepitant based on as-grown un-doped iron oxide nanoparticles. ► Fabrication of efficient Aprepitant detection by simple and reliable I–V technique. ► Low-dimensional nanoparticles (diameter ∼75.4nm) are processed in rhombohedral geometry with 2.844.16eV band gap. ► It exhibits higher sensitivity (∼2.5316μAcm−2mM−1) and lower detection limit (0.38nM). We have prepared as-grown iron oxide nanoparticle by a solution method using reducing agents (urea and NH4OH) in alkaline phase. The nanoparticles were characterized by UV/vis, FT-IR, and Raman spectroscopy, powder X-ray diffraction, and field-emission scanning electron microscopy. They were deposited on a glassy carbon electrode (GCE, surface area, 0.0316cm2) to give a sensor with a fast response towards Aprepitant (APPT) drug in buffer phase. The sensor also exhibits good sensitivity and long-term stability as well as enhanced electrochemical response. The calibration plot is linear (r2=0.9703) over the 2.2nM to 4.1μM APPT concentration range. The sensitivity is ∼2.5316±0.5μAcm−2mM−1, and the detection limit is 0.38±0.02nM (at a signal-to-noise-ratio of 3) in short response time (10s). This method could also be employed for the determination of drugs in quality control of formulation using a reliable I–V method.