A comparative study of immunoglobulin IgM and rheumatoid factor IgMRF in solution by small-angle X-ray scattering

A comparative study of immunoglobulin IgM and rheumatoid factor IgMRF in solution by small-angle X-ray scattering

The shapes of rheumatoid factor molecules calculated from X-ray small-angle solution scattering data suggest that the peripheral Fab regions of rheumatoid factor in solution are more flocculent because of a higher flexibility of Fab domains.

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Veröffentlicht in:Mendeleev communications 2012-05, Vol.22 (3), p.159-161
Hauptverfasser: Volkov, Vladimir V., Lapuk, Victor A., Toropova, Anna I., Varlamova, Elena Yu, Shtykova, Eleonora V., Dembo, Kirill A., Timofeev, Vladimir P.
Format: Artikel
Sprache:eng
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Zusammenfassung:The shapes of rheumatoid factor molecules calculated from X-ray small-angle solution scattering data suggest that the peripheral Fab regions of rheumatoid factor in solution are more flocculent because of a higher flexibility of Fab domains.
ISSN:0959-9436
DOI:10.1016/j.mencom.2012.05.017