Tripeptide self-assembled hydrogels: unexpected twists of chirality

Tripeptide self-assembled hydrogels: unexpected twists of chirality

Change of chirality of the first N-terminal amino acid of tripeptides VFF and FFV from l to d results in self-assembled hydrogels at physiological pH from non-assembling l-analogues. Interestingly, changing the chirality of F yields very different nanostructures; nanotapes are observed for (D)VFF, t...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-02, Vol.48 (16), p.2195-2197
Hauptverfasser: Marchesan, Silvia, Easton, Christopher D, Kushkaki, Firdawosia, Waddington, Lynne, Hartley, Patrick G
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Chirality
Circular Dichroism
Fibers
Hydrogels
Hydrogels - chemistry
Isomerism
Nanocomposites
Nanomaterials
Nanostructure
Nanostructures - chemistry
Nanostructures - ultrastructure
Oligopeptides - chemistry
Rheology
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Zusammenfassung:Change of chirality of the first N-terminal amino acid of tripeptides VFF and FFV from l to d results in self-assembled hydrogels at physiological pH from non-assembling l-analogues. Interestingly, changing the chirality of F yields very different nanostructures; nanotapes are observed for (D)VFF, twisted fibers for (D)FFV.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc16609g