Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides

Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides

Hybrid Fe(3)O(4)@SiO(2)@PEG-Maltose MNPs were synthesized by SI-ATRP of branched PEG brushes on the surface and subsequent functionalization with hydrophilic maltose group, and the multifunctional materials were utilized for selective enrichment of N-linked glycopeptides from biological samples with...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (65), p.8138-8140
Hauptverfasser: Xiong, Zhichao, Zhao, Liang, Wang, Fangjun, Zhu, Jun, Qin, Hongqiang, Wu, Ren'an, Zhang, Weibing, Zou, Hanfa
Format: Artikel
Sprache:eng
Schlagworte:
Binding
Branched
Brushes
Enrichment
Ferrosoferric Oxide - chemistry
Glycopeptides
Glycopeptides - chemistry
Glycopeptides - isolation & purification
Glycosylation
Humans
Hydrophobic and Hydrophilic Interactions
Immunoglobulin G - chemistry
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - ultrastructure
Maltose - chemistry
Multifunctional materials
Nanoparticles
Polyethylene Glycols - chemistry
Sensitivity and Specificity
Silicon Dioxide - chemistry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Synthesis
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Zusammenfassung:Hybrid Fe(3)O(4)@SiO(2)@PEG-Maltose MNPs were synthesized by SI-ATRP of branched PEG brushes on the surface and subsequent functionalization with hydrophilic maltose group, and the multifunctional materials were utilized for selective enrichment of N-linked glycopeptides from biological samples with high specifity, high sensitivity, and large binding capacity.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc33600f