Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-Catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes

Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-Catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes

The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction provides good yields of optically active cyclohexenes featuring diverse substitution patterns and up to three stereocenters. Key to the success of the process is the use of new...

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Veröffentlicht in:Journal of the American Chemical Society 2012-09, Vol.134 (35), p.14322-14325
Hauptverfasser: Francos, Javier, Grande-Carmona, Francisca, Faustino, Hélio, Iglesias-Sigüenza, Javier, Díez, Elena, Alonso, Isaac, Fernández, Rosario, Lassaletta, José M, López, Fernando, Mascareñas, José L
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Sprache:eng
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Zusammenfassung:The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction provides good yields of optically active cyclohexenes featuring diverse substitution patterns and up to three stereocenters. Key to the success of the process is the use of newly designed axially chiral N-heterocyclic carbene–gold catalysts.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja3065446