Effect of tenofovir, an antiretroviral drug, on hepatic and renal functional indices of Wistar rats: protective role of vitamin E

Tenofovir (TFR) is a nucleotide reverse transcriptase inhibitor with activity against human immunodeficiency virus. We studied the effect of TFR administered to Wistar rats on hepatic and renal function markers and the possible modulatory role of vitamin E (Vit E). The study consists of four groups...

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Veröffentlicht in:	Journal of basic and clinical physiology and pharmacology 2012-08, Vol.23 (2), p.69-75
Hauptverfasser:	Adaramoye, Oluwatosin Adekunle, Adewumi, Olubusuyi Moses, Adesanoye, Omolola Abidemi, Faokunla, Opeyemi Olubunmi, Farombi, Ebenezer Olatunde
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - toxicity Animals Anti-HIV Agents - toxicity Antioxidants - metabolism Antioxidants - pharmacology kidney Kidney - drug effects Kidney - metabolism Kidney Function Tests liver Liver - drug effects Liver - metabolism Liver Function Tests Male Malondialdehyde - metabolism Organophosphonates - toxicity Oxidative Stress - drug effects Rats Rats, Wistar Tenofovir toxicity vitamin E Vitamin E - pharmacology
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Zusammenfassung:	Tenofovir (TFR) is a nucleotide reverse transcriptase inhibitor with activity against human immunodeficiency virus. We studied the effect of TFR administered to Wistar rats on hepatic and renal function markers and the possible modulatory role of vitamin E (Vit E). The study consists of four groups of six rats each. The first group served as control, the second group received TFR at 50 mg/kg/day for 4 weeks, third group received TFR and Vit E, and the last group received Vit E alone. TFR administration caused a significant (p
ISSN:	0792-6855 2191-0286
DOI:	10.1515/jbcpp.2011.0042