Nitric Oxide Delivery by Core/Shell Superparamagnetic Nanoparticle Vehicles with Enhanced Biocompatibility

We report the synthesis of Fe3O4/silica core/shell nanoparticles and their functionalization with S-nitrosothiols. These nanoparticles are of immense interest because of their nitric oxide (NO) release capabilities in human alveolar epithelial cells. Moreover, they act as large storage reservoirs of...

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Veröffentlicht in:	Langmuir 2012-09, Vol.28 (35), p.12879-12885
Hauptverfasser:	Zhang, X. F, Mansouri, S, Mbeh, D. A, Yahia, L’H, Sacher, E, Veres, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials - chemistry Biocompatible Materials - toxicity Biological Transport Cell Line, Tumor Cell Survival - drug effects Chemistry Colloidal state and disperse state Drug Carriers - chemistry Drug Carriers - toxicity Exact sciences and technology General and physical chemistry Humans Magnetite Nanoparticles - chemistry Nitric Oxide - chemistry Nitric Oxide - metabolism Permeability Physical and chemical studies. Granulometry. Electrokinetic phenomena S-Nitrosothiols - chemistry Silicon Dioxide - chemistry
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