Nitric Oxide Delivery by Core/Shell Superparamagnetic Nanoparticle Vehicles with Enhanced Biocompatibility

We report the synthesis of Fe3O4/silica core/shell nanoparticles and their functionalization with S-nitrosothiols. These nanoparticles are of immense interest because of their nitric oxide (NO) release capabilities in human alveolar epithelial cells. Moreover, they act as large storage reservoirs of...

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Veröffentlicht in:	Langmuir 2012-09, Vol.28 (35), p.12879-12885
Hauptverfasser:	Zhang, X. F, Mansouri, S, Mbeh, D. A, Yahia, L’H, Sacher, E, Veres, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials - chemistry Biocompatible Materials - toxicity Biological Transport Cell Line, Tumor Cell Survival - drug effects Chemistry Colloidal state and disperse state Drug Carriers - chemistry Drug Carriers - toxicity Exact sciences and technology General and physical chemistry Humans Magnetite Nanoparticles - chemistry Nitric Oxide - chemistry Nitric Oxide - metabolism Permeability Physical and chemical studies. Granulometry. Electrokinetic phenomena S-Nitrosothiols - chemistry Silicon Dioxide - chemistry
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Beschreibung
Zusammenfassung:	We report the synthesis of Fe3O4/silica core/shell nanoparticles and their functionalization with S-nitrosothiols. These nanoparticles are of immense interest because of their nitric oxide (NO) release capabilities in human alveolar epithelial cells. Moreover, they act as large storage reservoirs of NO that can be targeted magnetically to the specific site with a sustainable release of NO for up to 50 h. Such nanoparticles provide an enhancement of the biocompatibility with released NO while allowing intracellular accumulation ascribed to their small size.
ISSN:	0743-7463 1520-5827
DOI:	10.1021/la302357h