Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety

A series of 5-bromo-2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)pyrimidine were prepared under conventional heating as well as microwave reaction condition. The newly synthesized compounds were characterized on the basis of elemental, spectral and single crystal X-ray studies. These new compounds were screened for their antioxidant, anti-inflammatory and analgesic activities. Some of these compounds exhibited potent biological activities compared to the standard drug. A novel series of pyrazolines were synthesized under MW and evaluated for varies biological activities. Few compounds displayed excellent pharmacological property. [Display omitted] ► Microwave mediated synthesis of novel pyrazolines was achieved. ► Formation of pyrazoline was confirmed based on XRD studies. ► Results of antioxidant studies are highly encouraging. ► Few compounds displayed excellent anti-inflammatory and analgesic activity.