Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein

Highlights ► Regulatable expression of human wild-type alpha-synuclein in the SVZ/OB neurogenic region. ► Impaired adult OB neurogenesis partially rescued in GCL/GLOM. ► Rescue of newly generated dopaminergic neurons in the OB. ► Intracytoplasmic BrdU+ particles within microglia indicate phagocytosi...

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Veröffentlicht in:	Neuroscience 2012-10, Vol.222, p.343-355
Hauptverfasser:	May, V.E.L, Nuber, S, Marxreiter, F, Riess, O, Winner, B, Winkler, J
Format:	Artikel
Sprache:	eng
Schlagworte:	adult neurogenesis alpha-Synuclein - metabolism alpha-Synuclein - physiology Animals Antimetabolites Biological and medical sciences Biomarkers - metabolism Blotting, Western Brain - pathology Bromodeoxyuridine Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology Cell Count Cell Differentiation - physiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Inflammation - pathology Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic microglia Nerve Tissue Proteins - metabolism neural progenitor cells Neurogenesis - physiology Neuroglia - drug effects Neuroglia - physiology Neurology Nuclear Proteins - metabolism Olfactory Bulb - growth & development Olfactory Bulb - metabolism Olfactory system and olfaction. Gustatory system and gustation Parkinson’s disease synucleinopathy tet-off Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► Regulatable expression of human wild-type alpha-synuclein in the SVZ/OB neurogenic region. ► Impaired adult OB neurogenesis partially rescued in GCL/GLOM. ► Rescue of newly generated dopaminergic neurons in the OB. ► Intracytoplasmic BrdU+ particles within microglia indicate phagocytosis of new NPC.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.07.001