Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors

Graphical abstract Highlights ► Postsynaptic depolarisation accelerates the hypoxic depression of glutamate release. ► This process is Ca2+ - and PKC-dependent and may entail postsynaptic membrane fusion. ► In addition, this process requires activation of GI mGluRs, but not CB1 receptors. ► We propo...

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Veröffentlicht in:	Neuroscience 2012-10, Vol.222, p.159-172
Hauptverfasser:	Nuritova, F, Frenguelli, B.G
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine Adenosine - physiology Analysis of Variance Animals Biological and medical sciences CA1 Region, Hippocampal - physiopathology Calcium Signaling - drug effects Ethylmaleimide - pharmacology Female Fundamental and applied biological sciences. Psychology Glutamic Acid - physiology Guanosine Diphosphate - analogs & derivatives Guanosine Diphosphate - pharmacology hypoxia Hypoxia, Brain - physiopathology ischemia Male mGluR Neurology Patch-Clamp Techniques Piperidines - pharmacology Protein Kinase C - physiology Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 - drug effects Receptors, Metabotropic Glutamate - physiology retrograde signalling Signal Transduction - physiology Synaptic Transmission - physiology Thionucleotides - pharmacology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Graphical abstract Highlights ► Postsynaptic depolarisation accelerates the hypoxic depression of glutamate release. ► This process is Ca2+ - and PKC-dependent and may entail postsynaptic membrane fusion. ► In addition, this process requires activation of GI mGluRs, but not CB1 receptors. ► We propose a novel form of retrograde signalling activated by metabolic stress.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.07.034