The serum hepcidin:ferritin ratio is a potential biomarker for cirrhosis

The serum hepcidin:ferritin ratio is a potential biomarker for cirrhosis

Background Serum hepcidin concentration is potentially affected by inflammation and iron stores in chronic liver disease (CLD), but little is known about the relationship between hepcidin and the degree of hepatic fibrosis. We investigated the potential role of serum hepcidin as a biomarker of advan...

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Veröffentlicht in:Liver international 2012-10, Vol.32 (9), p.1391-1399
Hauptverfasser: Tan, Terrence C. H., Crawford, Darrell H. G., Franklin, Michael E., Jaskowski, Lesley A., Macdonald, Graeme A., Jonsson, Julie R., Watson, Melanie J., Taylor, Paul J., Fletcher, Linda M.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Alanine Transaminase - blood
Antimicrobial Cationic Peptides - blood
Antimicrobial Cationic Peptides - genetics
Bilirubin - blood
Biomarkers - metabolism
Chronic Disease
Disease Progression
Female
Ferritins - blood
Ferritins - genetics
Gene Expression
Hemoglobins - analysis
hepatic fibrosis
Hepcidins
Humans
iron metabolism
Liver - metabolism
Liver - pathology
Liver Cirrhosis - diagnosis
Liver Cirrhosis - genetics
Liver Cirrhosis - metabolism
Liver Failure - diagnosis
Liver Failure - genetics
Liver Failure - metabolism
Liver Function Tests
liver injury
Male
Middle Aged
Predictive Value of Tests
ROC Curve
Serum Albumin - analysis
Transferrins - blood
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Zusammenfassung:Background Serum hepcidin concentration is potentially affected by inflammation and iron stores in chronic liver disease (CLD), but little is known about the relationship between hepcidin and the degree of hepatic fibrosis. We investigated the potential role of serum hepcidin as a biomarker of advanced liver disease. Methods Serum hepcidin was measured in 332 adults with CLD of varying aetiologies, 45 healthy and 50 non‐liver disease patient controls. Liver biopsy data were available for 228 CLD subjects. Results Hepcidin was decreased in CLD patients compared with non‐liver disease patient controls (P 
ISSN:1478-3223
1478-3231
DOI:10.1111/j.1478-3231.2012.02828.x