Baseline serum immunoglobulin levels in patients with rheumatoid arthritis: relationships with clinical parameters and with B-cell dynamics following rituximab

To investigate whether levels of serum immunoglobulins (sIgs) at baseline were associated with clinical parameters or B-cell dynamics following rituximab (RTX) in patients with rheumatoid arthritis (RA). Baseline Ig levels, C-reactive protein (CRP), DAS28 and CD19+ve B-cell count (baseline, 1, 3 and...

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Veröffentlicht in:	Clinical and experimental rheumatology 2012-07, Vol.30 (4), p.554-560
Hauptverfasser:	DE LA TORRE, I, LEANDRO, M. J, EDWARDS, J. C. W, CAMBRIDGE, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Murine-Derived - therapeutic use Antigens, CD19 - metabolism Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology B-Lymphocytes - immunology B-Lymphocytes - metabolism Biological and medical sciences C-Reactive Protein - metabolism Diseases of the osteoarticular system Drug Monitoring - methods Female Humans Immunoglobulin A - blood Immunoglobulin G - blood Immunoglobulin M - blood Immunoglobulins - blood Immunomodulators Inflammatory joint diseases Male Medical sciences Middle Aged Pharmacology. Drug treatments Plasma Cells - immunology Plasma Cells - metabolism Rituximab Secondary Prevention
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Zusammenfassung:	To investigate whether levels of serum immunoglobulins (sIgs) at baseline were associated with clinical parameters or B-cell dynamics following rituximab (RTX) in patients with rheumatoid arthritis (RA). Baseline Ig levels, C-reactive protein (CRP), DAS28 and CD19+ve B-cell count (baseline, 1, 3 and 5 months) in 112 patients with RA after 1 cycle of RTX were included. All showed adequate B-cell depletion (
ISSN:	0392-856X 1593-098X