Association of −55CT polymorphism of UCP3 gene with fat distribution, cardiovascular risk factors and adipocytokines in patients with Type 2 diabetes mellitus
Background and aims: Some studies have pointed to a role of uncoupling protein 3 (UCP3) in the regulation of fat distribution. The aim of our study was to investigate the influence of −55CT polymorphism of UCP3 gene on fat mass and adipocytokines in naïve patients with Type 2 diabetes mellitus. Desi...
Gespeichert in:
| Veröffentlicht in: | Journal of endocrinological investigation 2012-07, Vol.35 (7), p.625-628 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 628 |
|---|---|
| container_issue | 7 |
| container_start_page | 625 |
| container_title | Journal of endocrinological investigation |
| container_volume | 35 |
| creator | de Luis, D. A. Aller, R. Izaola, O. Sagrado, M. González Conde, R. |
| description | Background and aims:
Some studies have pointed to a role of uncoupling protein 3 (UCP3) in the regulation of fat distribution. The aim of our study was to investigate the influence of −55CT polymorphism of UCP3 gene on fat mass and adipocytokines in naïve patients with Type 2 diabetes mellitus.
Design:
A population of 57 patients with Type 2 diabetes mellitus and obesity was analyzed in a cross-sectional study. Genotype of UCP3 gene −55CT was studied.
Results:
Forty-six patients (80.7%) had the 55CC genotype and 11 patients (19.3%) the 55CT genotype. Fat mass (39.1 ±15.4
vs
53.3±16.8 kg;
p |
| doi_str_mv | 10.3275/7908 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1036882496</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2665136534</sourcerecordid><originalsourceid>FETCH-LOGICAL-p199t-40295281b58b46b35d3c263211d3094d0b369716e6f50e687583fb82d342d433</originalsourceid><addsrcrecordid>eNpdkc-KFDEQxoMo7rjrK0hABA-OJqlOOjkug_9gQQ_juUl30rvZ7U7aVFqZN_DsE_hsPokZZkXwVFD1q6--qiLkgrPXIFr5pjVMPyAb3gq21aDVQ7JhYPi2YaY9I08QbxmDFnT7mJwJrk3LudiQX5eIaQi2hBRpGunvHz-l3O3pkqbDnPJyE3A-5r_sPgO99tHT76Hc0NEW6gKWHPr12PqKDja7kL5ZHNbJZpoD3lVqKCkjtdFR68KShkNJdyF6pCHSpQ71seBJcX9YPBVV1Pa-VGD20xTKihfk0Wgn9E_v4znZv3u7333YXn16_3F3ebVduDGlbimMFJr3UveN6kE6GIQCwbkDZhrHelB1ZeXVKJlXupUaxl4LB41wDcA5eXmSXXL6unos3RxwqB5s9GnFjjNQWovGqIo-_w-9TWuO1VwnlJIclISmUs_uqbWfveuWHGabD93f01fgxQnAWorXPv-T4aw7vrQ7vhT-AFrokNI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2665136534</pqid></control><display><type>article</type><title>Association of −55CT polymorphism of UCP3 gene with fat distribution, cardiovascular risk factors and adipocytokines in patients with Type 2 diabetes mellitus</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>de Luis, D. A. ; Aller, R. ; Izaola, O. ; Sagrado, M. González ; Conde, R.</creator><creatorcontrib>de Luis, D. A. ; Aller, R. ; Izaola, O. ; Sagrado, M. González ; Conde, R.</creatorcontrib><description><![CDATA[Background and aims:
Some studies have pointed to a role of uncoupling protein 3 (UCP3) in the regulation of fat distribution. The aim of our study was to investigate the influence of −55CT polymorphism of UCP3 gene on fat mass and adipocytokines in naïve patients with Type 2 diabetes mellitus.
Design:
A population of 57 patients with Type 2 diabetes mellitus and obesity was analyzed in a cross-sectional study. Genotype of UCP3 gene −55CT was studied.
Results:
Forty-six patients (80.7%) had the 55CC genotype and 11 patients (19.3%) the 55CT genotype. Fat mass (39.1 ±15.4
vs
53.3±16.8 kg;
p
<0.05), weight (92.6±17.7
vs
106.3±17.3 kg;
p
<0.05), body mass index (36.2±6.5
vs
42.8±5.2 kg/m
2
;
p
<0.05), waist circumference (112.8±13.6
vs
127.9±12.3 cm;
p
<0.05), waist-to-hip ratio (0.96±0.1
vs
1.1 ±0.2;
p
<0.05), C reactive protein (6.1 ±5.1
vs
12.4±6.1 mg/dl;
p
<0.05) and leptin (92.8±86
vs
114±89 ng/ml;
p
<0.05) were higher in patients with mutant genotype than in those with wild genotype.
Conclusion
: C reactive protein and fat mass were higher in the mutant group of −55 CT UCP3 gene diabetic patients than in wild type patients.]]></description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.3275/7908</identifier><identifier>PMID: 21897112</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adiposity ; Aged ; Body fat ; Body Fat Distribution ; Body Mass Index ; C-reactive protein ; C-Reactive Protein - analysis ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Endocrinology ; Female ; Gene polymorphism ; Genetic Association Studies ; Genotype & phenotype ; Humans ; Ion Channels - genetics ; Ion Channels - metabolism ; Leptin ; Leptin - blood ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Mitochondrial Proteins - genetics ; Mitochondrial Proteins - metabolism ; Mutants ; Mutation ; Obesity - complications ; Obesity - genetics ; Obesity - metabolism ; Obesity - physiopathology ; Original Article ; Polymorphism ; Polymorphism, Genetic ; Promoter Regions, Genetic ; Proteins ; Risk Factors ; Spain - epidemiology ; Uncoupling Protein 3</subject><ispartof>Journal of endocrinological investigation, 2012-07, Vol.35 (7), p.625-628</ispartof><rights>Italian Society of Endocrinology (SIE) 2012</rights><rights>Italian Society of Endocrinology (SIE) 2012.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p199t-40295281b58b46b35d3c263211d3094d0b369716e6f50e687583fb82d342d433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.3275/7908$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.3275/7908$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21897112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Luis, D. A.</creatorcontrib><creatorcontrib>Aller, R.</creatorcontrib><creatorcontrib>Izaola, O.</creatorcontrib><creatorcontrib>Sagrado, M. González</creatorcontrib><creatorcontrib>Conde, R.</creatorcontrib><title>Association of −55CT polymorphism of UCP3 gene with fat distribution, cardiovascular risk factors and adipocytokines in patients with Type 2 diabetes mellitus</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description><![CDATA[Background and aims:
Some studies have pointed to a role of uncoupling protein 3 (UCP3) in the regulation of fat distribution. The aim of our study was to investigate the influence of −55CT polymorphism of UCP3 gene on fat mass and adipocytokines in naïve patients with Type 2 diabetes mellitus.
Design:
A population of 57 patients with Type 2 diabetes mellitus and obesity was analyzed in a cross-sectional study. Genotype of UCP3 gene −55CT was studied.
Results:
Forty-six patients (80.7%) had the 55CC genotype and 11 patients (19.3%) the 55CT genotype. Fat mass (39.1 ±15.4
vs
53.3±16.8 kg;
p
<0.05), weight (92.6±17.7
vs
106.3±17.3 kg;
p
<0.05), body mass index (36.2±6.5
vs
42.8±5.2 kg/m
2
;
p
<0.05), waist circumference (112.8±13.6
vs
127.9±12.3 cm;
p
<0.05), waist-to-hip ratio (0.96±0.1
vs
1.1 ±0.2;
p
<0.05), C reactive protein (6.1 ±5.1
vs
12.4±6.1 mg/dl;
p
<0.05) and leptin (92.8±86
vs
114±89 ng/ml;
p
<0.05) were higher in patients with mutant genotype than in those with wild genotype.
Conclusion
: C reactive protein and fat mass were higher in the mutant group of −55 CT UCP3 gene diabetic patients than in wild type patients.]]></description><subject>Adiposity</subject><subject>Aged</subject><subject>Body fat</subject><subject>Body Fat Distribution</subject><subject>Body Mass Index</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic Association Studies</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Ion Channels - genetics</subject><subject>Ion Channels - metabolism</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Mitochondrial Proteins - genetics</subject><subject>Mitochondrial Proteins - metabolism</subject><subject>Mutants</subject><subject>Mutation</subject><subject>Obesity - complications</subject><subject>Obesity - genetics</subject><subject>Obesity - metabolism</subject><subject>Obesity - physiopathology</subject><subject>Original Article</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Promoter Regions, Genetic</subject><subject>Proteins</subject><subject>Risk Factors</subject><subject>Spain - epidemiology</subject><subject>Uncoupling Protein 3</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc-KFDEQxoMo7rjrK0hABA-OJqlOOjkug_9gQQ_juUl30rvZ7U7aVFqZN_DsE_hsPokZZkXwVFD1q6--qiLkgrPXIFr5pjVMPyAb3gq21aDVQ7JhYPi2YaY9I08QbxmDFnT7mJwJrk3LudiQX5eIaQi2hBRpGunvHz-l3O3pkqbDnPJyE3A-5r_sPgO99tHT76Hc0NEW6gKWHPr12PqKDja7kL5ZHNbJZpoD3lVqKCkjtdFR68KShkNJdyF6pCHSpQ71seBJcX9YPBVV1Pa-VGD20xTKihfk0Wgn9E_v4znZv3u7333YXn16_3F3ebVduDGlbimMFJr3UveN6kE6GIQCwbkDZhrHelB1ZeXVKJlXupUaxl4LB41wDcA5eXmSXXL6unos3RxwqB5s9GnFjjNQWovGqIo-_w-9TWuO1VwnlJIclISmUs_uqbWfveuWHGabD93f01fgxQnAWorXPv-T4aw7vrQ7vhT-AFrokNI</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>de Luis, D. A.</creator><creator>Aller, R.</creator><creator>Izaola, O.</creator><creator>Sagrado, M. González</creator><creator>Conde, R.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Association of −55CT polymorphism of UCP3 gene with fat distribution, cardiovascular risk factors and adipocytokines in patients with Type 2 diabetes mellitus</title><author>de Luis, D. A. ; Aller, R. ; Izaola, O. ; Sagrado, M. González ; Conde, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p199t-40295281b58b46b35d3c263211d3094d0b369716e6f50e687583fb82d342d433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adiposity</topic><topic>Aged</topic><topic>Body fat</topic><topic>Body Fat Distribution</topic><topic>Body Mass Index</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic Association Studies</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Ion Channels - genetics</topic><topic>Ion Channels - metabolism</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Mitochondrial Proteins - genetics</topic><topic>Mitochondrial Proteins - metabolism</topic><topic>Mutants</topic><topic>Mutation</topic><topic>Obesity - complications</topic><topic>Obesity - genetics</topic><topic>Obesity - metabolism</topic><topic>Obesity - physiopathology</topic><topic>Original Article</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Promoter Regions, Genetic</topic><topic>Proteins</topic><topic>Risk Factors</topic><topic>Spain - epidemiology</topic><topic>Uncoupling Protein 3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Luis, D. A.</creatorcontrib><creatorcontrib>Aller, R.</creatorcontrib><creatorcontrib>Izaola, O.</creatorcontrib><creatorcontrib>Sagrado, M. González</creatorcontrib><creatorcontrib>Conde, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Luis, D. A.</au><au>Aller, R.</au><au>Izaola, O.</au><au>Sagrado, M. González</au><au>Conde, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of −55CT polymorphism of UCP3 gene with fat distribution, cardiovascular risk factors and adipocytokines in patients with Type 2 diabetes mellitus</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>35</volume><issue>7</issue><spage>625</spage><epage>628</epage><pages>625-628</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract><![CDATA[Background and aims:
Some studies have pointed to a role of uncoupling protein 3 (UCP3) in the regulation of fat distribution. The aim of our study was to investigate the influence of −55CT polymorphism of UCP3 gene on fat mass and adipocytokines in naïve patients with Type 2 diabetes mellitus.
Design:
A population of 57 patients with Type 2 diabetes mellitus and obesity was analyzed in a cross-sectional study. Genotype of UCP3 gene −55CT was studied.
Results:
Forty-six patients (80.7%) had the 55CC genotype and 11 patients (19.3%) the 55CT genotype. Fat mass (39.1 ±15.4
vs
53.3±16.8 kg;
p
<0.05), weight (92.6±17.7
vs
106.3±17.3 kg;
p
<0.05), body mass index (36.2±6.5
vs
42.8±5.2 kg/m
2
;
p
<0.05), waist circumference (112.8±13.6
vs
127.9±12.3 cm;
p
<0.05), waist-to-hip ratio (0.96±0.1
vs
1.1 ±0.2;
p
<0.05), C reactive protein (6.1 ±5.1
vs
12.4±6.1 mg/dl;
p
<0.05) and leptin (92.8±86
vs
114±89 ng/ml;
p
<0.05) were higher in patients with mutant genotype than in those with wild genotype.
Conclusion
: C reactive protein and fat mass were higher in the mutant group of −55 CT UCP3 gene diabetic patients than in wild type patients.]]></abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>21897112</pmid><doi>10.3275/7908</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0391-4097 |
| ispartof | Journal of endocrinological investigation, 2012-07, Vol.35 (7), p.625-628 |
| issn | 0391-4097 1720-8386 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1036882496 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adiposity Aged Body fat Body Fat Distribution Body Mass Index C-reactive protein C-Reactive Protein - analysis Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cross-Sectional Studies Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Endocrinology Female Gene polymorphism Genetic Association Studies Genotype & phenotype Humans Ion Channels - genetics Ion Channels - metabolism Leptin Leptin - blood Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Mutants Mutation Obesity - complications Obesity - genetics Obesity - metabolism Obesity - physiopathology Original Article Polymorphism Polymorphism, Genetic Promoter Regions, Genetic Proteins Risk Factors Spain - epidemiology Uncoupling Protein 3 |
| title | Association of −55CT polymorphism of UCP3 gene with fat distribution, cardiovascular risk factors and adipocytokines in patients with Type 2 diabetes mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T12%3A22%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20%E2%88%9255CT%20polymorphism%20of%20UCP3%20gene%20with%20fat%20distribution,%20cardiovascular%20risk%20factors%20and%20adipocytokines%20in%20patients%20with%20Type%202%20diabetes%20mellitus&rft.jtitle=Journal%20of%20endocrinological%20investigation&rft.au=de%20Luis,%20D.%20A.&rft.date=2012-07-01&rft.volume=35&rft.issue=7&rft.spage=625&rft.epage=628&rft.pages=625-628&rft.issn=0391-4097&rft.eissn=1720-8386&rft_id=info:doi/10.3275/7908&rft_dat=%3Cproquest_pubme%3E2665136534%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2665136534&rft_id=info:pmid/21897112&rfr_iscdi=true |