Association of −55CT polymorphism of UCP3 gene with fat distribution, cardiovascular risk factors and adipocytokines in patients with Type 2 diabetes mellitus

Background and aims: Some studies have pointed to a role of uncoupling protein 3 (UCP3) in the regulation of fat distribution. The aim of our study was to investigate the influence of −55CT polymorphism of UCP3 gene on fat mass and adipocytokines in naïve patients with Type 2 diabetes mellitus. Desi...

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Veröffentlicht in:	Journal of endocrinological investigation 2012-07, Vol.35 (7), p.625-628
Hauptverfasser:	de Luis, D. A., Aller, R., Izaola, O., Sagrado, M. González, Conde, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiposity Aged Body fat Body Fat Distribution Body Mass Index C-reactive protein C-Reactive Protein - analysis Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cross-Sectional Studies Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Endocrinology Female Gene polymorphism Genetic Association Studies Genotype & phenotype Humans Ion Channels - genetics Ion Channels - metabolism Leptin Leptin - blood Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Mutants Mutation Obesity - complications Obesity - genetics Obesity - metabolism Obesity - physiopathology Original Article Polymorphism Polymorphism, Genetic Promoter Regions, Genetic Proteins Risk Factors Spain - epidemiology Uncoupling Protein 3
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Zusammenfassung:	Background and aims: Some studies have pointed to a role of uncoupling protein 3 (UCP3) in the regulation of fat distribution. The aim of our study was to investigate the influence of −55CT polymorphism of UCP3 gene on fat mass and adipocytokines in naïve patients with Type 2 diabetes mellitus. Design: A population of 57 patients with Type 2 diabetes mellitus and obesity was analyzed in a cross-sectional study. Genotype of UCP3 gene −55CT was studied. Results: Forty-six patients (80.7%) had the 55CC genotype and 11 patients (19.3%) the 55CT genotype. Fat mass (39.1 ±15.4 vs 53.3±16.8 kg; p
ISSN:	0391-4097 1720-8386
DOI:	10.3275/7908