The critical care literature 2010

The current study was conducted from January 2007 to January 2009 and enrolled adult patients with confirmed or presumed infection, 2 or more criteria for the systemic inflammatory response syndrome, and evidence of hypoperfusion by either a systolic blood pressure (SBP) less than 90 mm Hg after a 20-mL/kg bolus of intravenous fluids (IVFs) or a blood lactate concentration greatercv than 4 mmol/L. [...]decreased cortisol levels can occur as soon as 30 minutes after a single dose and may persist for up to 24 hours [5-13]. [...]although the 1.5% absolute reduction in mortality reached statistical significance, is it clinically significant?