Comparison of vaccine efficacy for different antigen delivery systems for infectious pancreatic necrosis virus vaccines in Atlantic salmon ( Salmo salar L.) in a cohabitation challenge model

Highlights ► Inactivated whole viral (IWV) vaccines conferred good protection against IPN. ► Nanoparticle, sub-unit recombinant vaccines and DNA vaccine are inferior to IWV. ► Antibody levels were different between vaccine formulations. ► Highest antibody levels gave highest level of protection. ► P...

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Veröffentlicht in:	Vaccine 2012-06, Vol.30 (27), p.4007-4016
Hauptverfasser:	Munang’andu, Hetron M, Fredriksen, Børge N, Mutoloki, Stephen, Brudeseth, Bjørn, Kuo, Tsun-Yung, Marjara, Inderjit S, Dalmo, Roy A, Evensen, Øystein
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Viral - blood antigens Bacterial Toxins - genetics Birnaviridae Infections - prevention & control Birnaviridae Infections - veterinary carrier state Cohabitation Deoxyribonucleic acid DNA Drug Carriers - administration & dosage Escherichia coli Escherichia coli - genetics Fish Fish Diseases - prevention & control Fish Diseases - virology heat sums Inactivated whole virus Infections Infectious pancreatic necrosis virus Infectious pancreatic necrosis virus - immunology IPNV Marine Nanoparticles Nanoparticles - administration & dosage plasmids PLGA nanoparticles Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - genetics Recombinant recombinant vaccines Salmo salar Salmon Strain Studies Survival Analysis vaccination Vaccination - methods Vaccine Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - genetics Vaccines, Inactivated - immunology Vaccines, Subunit - administration & dosage Vaccines, Subunit - genetics Vaccines, Subunit - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology virulence Viruses
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Beschreibung
Zusammenfassung:	Highlights ► Inactivated whole viral (IWV) vaccines conferred good protection against IPN. ► Nanoparticle, sub-unit recombinant vaccines and DNA vaccine are inferior to IWV. ► Antibody levels were different between vaccine formulations. ► Highest antibody levels gave highest level of protection. ► Prevention of tissue damage was linked to protection against mortality.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.04.039