Elevated brain iron is independent from atrophy in Huntington's Disease

Increased iron in subcortical structures in patients with Huntington's Disease (HD) has been suggested as a causal factor of neuronal degeneration. The present study examines iron accumulation, measured using magnetic resonance imaging (MRI), in premanifest gene carriers and in early HD patient...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2012-07, Vol.61 (3), p.558-564
Hauptverfasser:	Dumas, Eve M., Versluis, Maarten J., van den Bogaard, Simon J.A., van Osch, Matthias J.P., Hart, Ellen P., van Roon-Mom, Willeke M.C., van Buchem, Mark A., Webb, Andrew G., van der Grond, Jeroen, Roos, Raymund A.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Aged Aging - physiology Amygdala Atrophy Brain - pathology Brain Chemistry - physiology Caudate Nucleus - metabolism Disease Progression Disease state Educational Status Electromagnetic Fields Female Heterozygote Humans Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Huntington's Disease Huntingtons disease Image Processing, Computer-Assisted Iron Iron - metabolism Logistic Models Magnetic field correlation Magnetic Resonance Imaging Male Middle Aged MRI Putamen - metabolism Sex Characteristics Volumetric analysis
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