Hematopoietic Stem Cell Heterogeneity Takes Center Stage

Over the past 10 years, increasing evidence has accumulated that heterogeneity is a feature of hematopoietic stem cell (HSC) proliferation, self-renewal, and differentiation based on examination of these properties at a clonal level. The heterogeneous behavior of HSCs reflects the operation of a com...

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Veröffentlicht in:	Cell stem cell 2012-06, Vol.10 (6), p.690-697
Hauptverfasser:	COPLEY, Michael R, BEER, Philip A, EAVES, Connie J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Clone Cells - pathology Fundamental and applied biological sciences. Psychology Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Humans Molecular and cellular biology Neoplasms - pathology Neoplasms - therapy
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Beschreibung
Zusammenfassung:	Over the past 10 years, increasing evidence has accumulated that heterogeneity is a feature of hematopoietic stem cell (HSC) proliferation, self-renewal, and differentiation based on examination of these properties at a clonal level. The heterogeneous behavior of HSCs reflects the operation of a complex interplay of intrinsic and extrinsic variables. In this review, we discuss key findings from the last 5 years that reveal new insights into the mechanisms involved.
ISSN:	1934-5909 1875-9777
DOI:	10.1016/j.stem.2012.05.006