Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides

Series of bis-oxy cyclophane diamides with m-terphenyl diamine as spacer have been synthesized. All the cyclophane diamides show good anti-inflammatory activity and some of the cyclophane diamides exhibited better anti-arthritic activity than the reference drug viz. diclofenac sodium. The cyclophane amide 4 and 5 do not show any evidence of mutagenicity and cytotoxicity in the assays employed. A series of bis-oxy cyclophane diamides with bis(aminomethyl)m-terphenyl as spacer have been synthesized and characterized from spectral and analytical data. All the cyclophane diamides exhibit better anti-arthritic activity than the reference drug viz. diclofenac sodium. Some of the cyclophane diamides exhibit good anti-inflammatory activity. The cyclophane amide 4 and 5 do not show any evidence of mutagenicity and cytotoxicity.