Correcting the Effects of −20 °C Storage and Aliquot Size on Erythrocyte Fatty Acid Content in the Women’s Health Initiative

Correcting the Effects of −20 °C Storage and Aliquot Size on Erythrocyte Fatty Acid Content in the Women’s Health Initiative

Red blood cell (RBC) fatty acid (FA) patterns have been shown to predict risk for cardiovascular and other chronic diseases. As part of a project analyzing RBC samples from the Women’s Health Initiative Memory Study (WHIMS) we observed implausibly low levels of highly unsaturated fatty acids (HUFA)...

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Veröffentlicht in:Lipids 2012-09, Vol.47 (9), p.835-846
Hauptverfasser: Pottala, James V., Espeland, Mark A., Polreis, Jason, Robinson, Jennifer, Harris, William S.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biomedical and Life Sciences
Calibration
Cryopreservation - standards
Erythrocyte
Erythrocytes
Erythrocytes - chemistry
Erythrocytes - metabolism
Fatty acids
Fatty Acids - analysis
Fatty Acids - metabolism
Fatty Acids, Unsaturated - analysis
Fatty Acids, Unsaturated - metabolism
Female
Gas chromatography
Health promotion
Health risks
Humans
Life Sciences
Lipidology
Medical Biochemistry
Medicinal Chemistry
Microbial Genetics and Genomics
Middle Aged
Multiple imputations
Neurochemistry
Nutrition
n‐3 Fatty acids
n‐6 Fatty acids
Original Article
Oxidation-Reduction
Specimen Handling - methods
Specimen Handling - standards
WHIMS
Women's Health
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Beschreibung
Zusammenfassung:Red blood cell (RBC) fatty acid (FA) patterns have been shown to predict risk for cardiovascular and other chronic diseases. As part of a project analyzing RBC samples from the Women’s Health Initiative Memory Study (WHIMS) we observed implausibly low levels of highly unsaturated fatty acids (HUFA) suggestive of degradation. This was hypothesized to be due to short term storage (
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-012-3693-y