Nod-like receptors in the control of intestinal inflammation

Highlights ► NLR proteins have been genetically associated with and studied in models of IBD. ► Mice deficient for specific NLRs are susceptible to bacterial and chemical colitis. ► NLR proteins are important mediators between the host and the resident microbiota. ► NLR proteins control innate cytok...

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Veröffentlicht in:	Current opinion in immunology 2012-08, Vol.24 (4), p.398-404
Hauptverfasser:	Rubino, Stephen J, Selvanantham, Thirumahal, Girardin, Stephen E, Philpott, Dana J
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Colitis, Ulcerative - immunology Crohn Disease - immunology Humans Mice Nod1 Signaling Adaptor Protein - physiology Nod2 Signaling Adaptor Protein - physiology Receptors, Cytoplasmic and Nuclear - physiology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights ► NLR proteins have been genetically associated with and studied in models of IBD. ► Mice deficient for specific NLRs are susceptible to bacterial and chemical colitis. ► NLR proteins are important mediators between the host and the resident microbiota. ► NLR proteins control innate cytokine responses and cellular proliferation.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2012.04.010