The induction of Treg cells by gut-indigenous Clostridium

The induction of Treg cells by gut-indigenous Clostridium

Highlights ► Regulatory T (Treg) cells are particularly abundant in the colonic mucosa. ► The components of the gut commensal microbiota, particularly clostridia, affect the development and function Treg cells. ► Clostridia are likely to provide antigens and a unique environment for the development...

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Veröffentlicht in:Current opinion in immunology 2012-08, Vol.24 (4), p.392-397
Hauptverfasser: Nagano, Yuji, Itoh, Kikuji, Honda, Kenya
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Clostridium - physiology
Colon - microbiology
Humans
Immune Tolerance
Intestinal Mucosa - microbiology
Metagenome
T-Lymphocytes, Regulatory - immunology
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Zusammenfassung:Highlights ► Regulatory T (Treg) cells are particularly abundant in the colonic mucosa. ► The components of the gut commensal microbiota, particularly clostridia, affect the development and function Treg cells. ► Clostridia are likely to provide antigens and a unique environment for the development of Treg cells.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2012.05.007