HBeAg seroconversion in children infected during early childhood with hepatitis B virus

Abstract Background Seroconversion of hepatitis B e-antigen (HBeAg) to anti-HBe is associated with lower viral load and liver diseases. Objectives The purpose of this study was to assess the seroconversion rate of HBeAg to anti-HBe in children who acquired hepatitis B virus (HBV) infection during ea...

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Veröffentlicht in:	Journal of clinical virology 2012-09, Vol.55 (1), p.30-33
Hauptverfasser:	Roushan, Mohammad Reza Hasanjani, Bijani, Ali, Ramzaninejad, Sodeh, Roushan, Mahbobeh Hasanjani, Amiri, Mohammad Jafar Soleimani, Baiani, Masomeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allergy and Immunology Anti-HBe Biological and medical sciences Child Child, Preschool Childhood Chronic HBV Epidemiology Female Fundamental and applied biological sciences. Psychology HBeAg Hepatitis Antibodies - blood Hepatitis Antibodies - immunology Hepatitis B e Antigens - blood Hepatitis B e Antigens - immunology Hepatitis B virus - immunology Hepatitis B, Chronic - immunology Hepatitis B, Chronic - virology Human viral diseases Humans Infectious Disease Infectious diseases Kaplan-Meier Estimate Male Medical sciences Microbiology Prospective Studies Seroconversion Viral diseases Viral hepatitis Virology
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Zusammenfassung:	Abstract Background Seroconversion of hepatitis B e-antigen (HBeAg) to anti-HBe is associated with lower viral load and liver diseases. Objectives The purpose of this study was to assess the seroconversion rate of HBeAg to anti-HBe in children who acquired hepatitis B virus (HBV) infection during early childhood. Study design From September 1990 to December 2010, 139 HBeAg-positive children were followed up. Eighty-one subjects were of failure of hepatitis B immune globulin (HBIG) and hepatitis B vaccine at birth and 58 children
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2012.05.007