Immune senescence and vaccines to prevent herpes zoster in older persons
Highlights ► Latent VZV is maintained in sensory neurons because of VZV-specific T-cell immunity. ► This immunity declines with age – the number/function of early effectors and effector memory. ► The loss of this T-cell immunity correlates with the occurrence of herpes zoster. ► A herpes zoster vacc...
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| Veröffentlicht in: | Current opinion in immunology 2012-08, Vol.24 (4), p.494-500 |
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| creator | Levin, Myron J |
| description | Highlights ► Latent VZV is maintained in sensory neurons because of VZV-specific T-cell immunity. ► This immunity declines with age – the number/function of early effectors and effector memory. ► The loss of this T-cell immunity correlates with the occurrence of herpes zoster. ► A herpes zoster vaccine can restore this immunity and prevent herpes zoster. ► Suggestions are offered to improve the efficacy of zoster vaccine. |
| doi_str_mv | 10.1016/j.coi.2012.06.002 |
| format | Article |
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| ispartof | Current opinion in immunology, 2012-08, Vol.24 (4), p.494-500 |
| issn | 0952-7915 1879-0372 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Aged, 80 and over Aging - immunology Allergy and Immunology Animals Herpes Zoster - prevention & control Herpes Zoster Vaccine - immunology Herpesvirus 3, Human - immunology Humans Immunity, Cellular - physiology T-Lymphocytes - immunology |
| title | Immune senescence and vaccines to prevent herpes zoster in older persons |
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