Immune senescence and vaccines to prevent herpes zoster in older persons

Highlights ► Latent VZV is maintained in sensory neurons because of VZV-specific T-cell immunity. ► This immunity declines with age – the number/function of early effectors and effector memory. ► The loss of this T-cell immunity correlates with the occurrence of herpes zoster. ► A herpes zoster vacc...

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Veröffentlicht in:	Current opinion in immunology 2012-08, Vol.24 (4), p.494-500
1. Verfasser:	Levin, Myron J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging - immunology Allergy and Immunology Animals Herpes Zoster - prevention & control Herpes Zoster Vaccine - immunology Herpesvirus 3, Human - immunology Humans Immunity, Cellular - physiology T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:	Highlights ► Latent VZV is maintained in sensory neurons because of VZV-specific T-cell immunity. ► This immunity declines with age – the number/function of early effectors and effector memory. ► The loss of this T-cell immunity correlates with the occurrence of herpes zoster. ► A herpes zoster vaccine can restore this immunity and prevent herpes zoster. ► Suggestions are offered to improve the efficacy of zoster vaccine.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2012.06.002