Multidrug-resistant clones of community-associated meticillin-resistant Staphylococcus aureus isolated from Chinese children and the resistance genes to clindamycin and mupirocin
This study aimed to correlate the multidrug resistance (MDR) and sequence type (ST) clones of community-associated (CA) meticillin-resistant Staphylococcus aureus (MRSA) to identify the genes responsible for clindamycin and mupirocin resistance in S. aureus isolates from paediatric hospitals in main...
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| Veröffentlicht in: | Journal of medical microbiology 2012-09, Vol.61 (9), p.1240-1247 |
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| creator | Wang, Lijuan Liu, Yingchao Yang, Yonghong Huang, Guoying Wang, Chuanqing Deng, Li Zheng, Yuejie Fu, Zhou Li, Changcong Shang, Yunxiao Zhao, Changan Sun, Mingjiao Li, Xiangmei Yu, Sangjie Yao, Kaihu Shen, Xuzhuang |
| description | This study aimed to correlate the multidrug resistance (MDR) and sequence type (ST) clones of community-associated (CA) meticillin-resistant Staphylococcus aureus (MRSA) to identify the genes responsible for clindamycin and mupirocin resistance in S. aureus isolates from paediatric hospitals in mainland China. A total of 435 S. aureus isolates were collected. Compared with CA meticillin-susceptible S. aureus (MSSA), the resistance rates of CA-MRSA to ciprofloxacin, chloramphenicol, gentamicin and tetracycline were higher (19.0 vs 2.6 %, P |
| doi_str_mv | 10.1099/jmm.0.042663-0 |
| format | Article |
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A total of 435 S. aureus isolates were collected. Compared with CA meticillin-susceptible S. aureus (MSSA), the resistance rates of CA-MRSA to ciprofloxacin, chloramphenicol, gentamicin and tetracycline were higher (19.0 vs 2.6 %, P<0.001; 14.7 vs 3.1 %, P<0.001; 14.7 vs 3.1 %, P<0.01; and 46.0 vs 13.3 %, P<0.001, respectively). Compared with hospital-associated (HA)-MRSA, the resistance rates of CA-MRSA to ciprofloxacin, gentamicin, rifampicin, tetracycline and trimethoprim-sulfamethoxazole were lower (19 vs 94.8 %, P<0.001; 14.7 vs 84.4 %, P<0.001; 5.5 vs 88.3 %, P<0.001; 46 vs 94.8 %, P<0.001; and 1.8 vs 9.1 %, P<0.01, respectively). The resistance rates of CA-MRSA, HA-MRSA and CA-MSSA to clindamycin (92.0, 77.9 and 64.1 %, respectively) and erythromycin (85.9, 77.9 and 63.1 %, respectively) were high. The MDR rates (resistance to three or more non-β-lactams) were 49.6, 100 and 14 % in the CA-MRSA, HA-MRSA and CA-MSSA isolates, respectively. Five of seven ST clones in the CA-MRSA isolates, namely ST59, ST338, ST45, ST910 and ST965, had MDR rates of >50 % (67.9, 87.5, 100, 50 and 83.3 %, respectively). The constitutive phenotype of macrolide-lincosamide-streptogramin B (MLS(B)) resistance (69 %) and the ermB gene (38.1 %) predominated among the MLS(B)-resistant CA S. aureus strains. The resistance rate to mupirocin was 2.3 % and plasmids carrying the mupA gene varied in size between 23 and 54.2 kb in six strains with high-level resistance as determined by Southern blot analysis. The present study showed that resistance to non-β-lactams, especially to clindamycin, is high in CA-MRSA isolates from Chinese children and that the profile of resistance is related to clonal type. This study revealed distinctive patterns of MLS(B)-resistant genes among CA S. aureus isolates.]]></description><identifier>ISSN: 0022-2615</identifier><identifier>EISSN: 1473-5644</identifier><identifier>DOI: 10.1099/jmm.0.042663-0</identifier><identifier>PMID: 22595913</identifier><identifier>CODEN: JMMIAV</identifier><language>eng</language><publisher>Reading: Society for General Microbiology</publisher><subject>Adolescent ; Anti-Bacterial Agents - pharmacology ; Bacteriology ; Biological and medical sciences ; Child ; Child, Preschool ; China ; Clindamycin - pharmacology ; Community-Acquired Infections - microbiology ; Drug Resistance, Multiple, Bacterial - genetics ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant ; Infant, Newborn ; Infectious diseases ; Medical sciences ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Methicillin-Resistant Staphylococcus aureus - metabolism ; Microbial Sensitivity Tests ; Microbiology ; Miscellaneous ; Mupirocin - pharmacology ; Sequence Analysis, DNA ; Staphylococcal Infections - microbiology ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - genetics ; Staphylococcus aureus - isolation & purification ; Staphylococcus aureus - metabolism</subject><ispartof>Journal of medical microbiology, 2012-09, Vol.61 (9), p.1240-1247</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-5f06f9b918e84a995fe9040ca34fca5f6ac11119b275319afb75f6447d7c5b6c3</citedby><cites>FETCH-LOGICAL-c391t-5f06f9b918e84a995fe9040ca34fca5f6ac11119b275319afb75f6447d7c5b6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3747,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26290379$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22595913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Lijuan</creatorcontrib><creatorcontrib>Liu, Yingchao</creatorcontrib><creatorcontrib>Yang, Yonghong</creatorcontrib><creatorcontrib>Huang, Guoying</creatorcontrib><creatorcontrib>Wang, Chuanqing</creatorcontrib><creatorcontrib>Deng, Li</creatorcontrib><creatorcontrib>Zheng, Yuejie</creatorcontrib><creatorcontrib>Fu, Zhou</creatorcontrib><creatorcontrib>Li, Changcong</creatorcontrib><creatorcontrib>Shang, Yunxiao</creatorcontrib><creatorcontrib>Zhao, Changan</creatorcontrib><creatorcontrib>Sun, Mingjiao</creatorcontrib><creatorcontrib>Li, Xiangmei</creatorcontrib><creatorcontrib>Yu, Sangjie</creatorcontrib><creatorcontrib>Yao, Kaihu</creatorcontrib><creatorcontrib>Shen, Xuzhuang</creatorcontrib><title>Multidrug-resistant clones of community-associated meticillin-resistant Staphylococcus aureus isolated from Chinese children and the resistance genes to clindamycin and mupirocin</title><title>Journal of medical microbiology</title><addtitle>J Med Microbiol</addtitle><description><![CDATA[This study aimed to correlate the multidrug resistance (MDR) and sequence type (ST) clones of community-associated (CA) meticillin-resistant Staphylococcus aureus (MRSA) to identify the genes responsible for clindamycin and mupirocin resistance in S. aureus isolates from paediatric hospitals in mainland China. A total of 435 S. aureus isolates were collected. Compared with CA meticillin-susceptible S. aureus (MSSA), the resistance rates of CA-MRSA to ciprofloxacin, chloramphenicol, gentamicin and tetracycline were higher (19.0 vs 2.6 %, P<0.001; 14.7 vs 3.1 %, P<0.001; 14.7 vs 3.1 %, P<0.01; and 46.0 vs 13.3 %, P<0.001, respectively). Compared with hospital-associated (HA)-MRSA, the resistance rates of CA-MRSA to ciprofloxacin, gentamicin, rifampicin, tetracycline and trimethoprim-sulfamethoxazole were lower (19 vs 94.8 %, P<0.001; 14.7 vs 84.4 %, P<0.001; 5.5 vs 88.3 %, P<0.001; 46 vs 94.8 %, P<0.001; and 1.8 vs 9.1 %, P<0.01, respectively). The resistance rates of CA-MRSA, HA-MRSA and CA-MSSA to clindamycin (92.0, 77.9 and 64.1 %, respectively) and erythromycin (85.9, 77.9 and 63.1 %, respectively) were high. The MDR rates (resistance to three or more non-β-lactams) were 49.6, 100 and 14 % in the CA-MRSA, HA-MRSA and CA-MSSA isolates, respectively. Five of seven ST clones in the CA-MRSA isolates, namely ST59, ST338, ST45, ST910 and ST965, had MDR rates of >50 % (67.9, 87.5, 100, 50 and 83.3 %, respectively). The constitutive phenotype of macrolide-lincosamide-streptogramin B (MLS(B)) resistance (69 %) and the ermB gene (38.1 %) predominated among the MLS(B)-resistant CA S. aureus strains. The resistance rate to mupirocin was 2.3 % and plasmids carrying the mupA gene varied in size between 23 and 54.2 kb in six strains with high-level resistance as determined by Southern blot analysis. The present study showed that resistance to non-β-lactams, especially to clindamycin, is high in CA-MRSA isolates from Chinese children and that the profile of resistance is related to clonal type. This study revealed distinctive patterns of MLS(B)-resistant genes among CA S. aureus isolates.]]></description><subject>Adolescent</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China</subject><subject>Clindamycin - pharmacology</subject><subject>Community-Acquired Infections - microbiology</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Methicillin-Resistant Staphylococcus aureus - genetics</subject><subject>Methicillin-Resistant Staphylococcus aureus - isolation & purification</subject><subject>Methicillin-Resistant Staphylococcus aureus - metabolism</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mupirocin - pharmacology</subject><subject>Sequence Analysis, DNA</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - genetics</subject><subject>Staphylococcus aureus - isolation & purification</subject><subject>Staphylococcus aureus - metabolism</subject><issn>0022-2615</issn><issn>1473-5644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkctuFDEQRS0EIkNgyxJ5g8SmB787XqIRj0hBLIB1y11tZxz5MdjuxfwWX4jDTAi1Kal07q1SXYReU7KlROv3dzFuyZYIphQfyBO0oWLkg1RCPEUbQhgbmKLyAr2o9Y4QOnKun6MLxqSWmvIN-v11Dc0vZb0diq2-NpMahpCTrTg7DDnGNfl2HEytGbxpdsHRNg8-BJ_-03xv5rA_hgwZYK3YrMX25msOfzWu5Ih3e999LYa9D0uxCZu04La3-MEGLL6196tb7kf4tJh4BH_i4nrwpZ-QXqJnzoRqX537Jfr56eOP3Zfh5tvn692HmwG4pm2QjiinZ02v7JUwWktnNREEDBcOjHTKAO2lZzZKTrVx89iHQozLCHJWwC_Ru5PvoeRfq61tir6CDcEkm9c6UcIF6y9VtKPbEwol11qsmw7FR1OOHZruc5p6ThOZTjlNpAvenL3XOdrlH_4QTAfengFTwQRX-nN8feQU04SPmv8BldShaQ</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Wang, Lijuan</creator><creator>Liu, Yingchao</creator><creator>Yang, Yonghong</creator><creator>Huang, Guoying</creator><creator>Wang, Chuanqing</creator><creator>Deng, Li</creator><creator>Zheng, Yuejie</creator><creator>Fu, Zhou</creator><creator>Li, Changcong</creator><creator>Shang, Yunxiao</creator><creator>Zhao, Changan</creator><creator>Sun, Mingjiao</creator><creator>Li, Xiangmei</creator><creator>Yu, Sangjie</creator><creator>Yao, Kaihu</creator><creator>Shen, Xuzhuang</creator><general>Society for General Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Multidrug-resistant clones of community-associated meticillin-resistant Staphylococcus aureus isolated from Chinese children and the resistance genes to clindamycin and mupirocin</title><author>Wang, Lijuan ; Liu, Yingchao ; Yang, Yonghong ; Huang, Guoying ; Wang, Chuanqing ; Deng, Li ; Zheng, Yuejie ; Fu, Zhou ; Li, Changcong ; Shang, Yunxiao ; Zhao, Changan ; Sun, Mingjiao ; Li, Xiangmei ; Yu, Sangjie ; Yao, Kaihu ; Shen, Xuzhuang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-5f06f9b918e84a995fe9040ca34fca5f6ac11119b275319afb75f6447d7c5b6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>China</topic><topic>Clindamycin - pharmacology</topic><topic>Community-Acquired Infections - microbiology</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Methicillin-Resistant Staphylococcus aureus - drug effects</topic><topic>Methicillin-Resistant Staphylococcus aureus - genetics</topic><topic>Methicillin-Resistant Staphylococcus aureus - isolation & purification</topic><topic>Methicillin-Resistant Staphylococcus aureus - metabolism</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mupirocin - pharmacology</topic><topic>Sequence Analysis, DNA</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - genetics</topic><topic>Staphylococcus aureus - isolation & purification</topic><topic>Staphylococcus aureus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Lijuan</creatorcontrib><creatorcontrib>Liu, Yingchao</creatorcontrib><creatorcontrib>Yang, Yonghong</creatorcontrib><creatorcontrib>Huang, Guoying</creatorcontrib><creatorcontrib>Wang, Chuanqing</creatorcontrib><creatorcontrib>Deng, Li</creatorcontrib><creatorcontrib>Zheng, Yuejie</creatorcontrib><creatorcontrib>Fu, Zhou</creatorcontrib><creatorcontrib>Li, Changcong</creatorcontrib><creatorcontrib>Shang, Yunxiao</creatorcontrib><creatorcontrib>Zhao, Changan</creatorcontrib><creatorcontrib>Sun, Mingjiao</creatorcontrib><creatorcontrib>Li, Xiangmei</creatorcontrib><creatorcontrib>Yu, Sangjie</creatorcontrib><creatorcontrib>Yao, Kaihu</creatorcontrib><creatorcontrib>Shen, Xuzhuang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Lijuan</au><au>Liu, Yingchao</au><au>Yang, Yonghong</au><au>Huang, Guoying</au><au>Wang, Chuanqing</au><au>Deng, Li</au><au>Zheng, Yuejie</au><au>Fu, Zhou</au><au>Li, Changcong</au><au>Shang, Yunxiao</au><au>Zhao, Changan</au><au>Sun, Mingjiao</au><au>Li, Xiangmei</au><au>Yu, Sangjie</au><au>Yao, Kaihu</au><au>Shen, Xuzhuang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multidrug-resistant clones of community-associated meticillin-resistant Staphylococcus aureus isolated from Chinese children and the resistance genes to clindamycin and mupirocin</atitle><jtitle>Journal of medical microbiology</jtitle><addtitle>J Med Microbiol</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>61</volume><issue>9</issue><spage>1240</spage><epage>1247</epage><pages>1240-1247</pages><issn>0022-2615</issn><eissn>1473-5644</eissn><coden>JMMIAV</coden><abstract><![CDATA[This study aimed to correlate the multidrug resistance (MDR) and sequence type (ST) clones of community-associated (CA) meticillin-resistant Staphylococcus aureus (MRSA) to identify the genes responsible for clindamycin and mupirocin resistance in S. aureus isolates from paediatric hospitals in mainland China. A total of 435 S. aureus isolates were collected. Compared with CA meticillin-susceptible S. aureus (MSSA), the resistance rates of CA-MRSA to ciprofloxacin, chloramphenicol, gentamicin and tetracycline were higher (19.0 vs 2.6 %, P<0.001; 14.7 vs 3.1 %, P<0.001; 14.7 vs 3.1 %, P<0.01; and 46.0 vs 13.3 %, P<0.001, respectively). Compared with hospital-associated (HA)-MRSA, the resistance rates of CA-MRSA to ciprofloxacin, gentamicin, rifampicin, tetracycline and trimethoprim-sulfamethoxazole were lower (19 vs 94.8 %, P<0.001; 14.7 vs 84.4 %, P<0.001; 5.5 vs 88.3 %, P<0.001; 46 vs 94.8 %, P<0.001; and 1.8 vs 9.1 %, P<0.01, respectively). The resistance rates of CA-MRSA, HA-MRSA and CA-MSSA to clindamycin (92.0, 77.9 and 64.1 %, respectively) and erythromycin (85.9, 77.9 and 63.1 %, respectively) were high. The MDR rates (resistance to three or more non-β-lactams) were 49.6, 100 and 14 % in the CA-MRSA, HA-MRSA and CA-MSSA isolates, respectively. Five of seven ST clones in the CA-MRSA isolates, namely ST59, ST338, ST45, ST910 and ST965, had MDR rates of >50 % (67.9, 87.5, 100, 50 and 83.3 %, respectively). The constitutive phenotype of macrolide-lincosamide-streptogramin B (MLS(B)) resistance (69 %) and the ermB gene (38.1 %) predominated among the MLS(B)-resistant CA S. aureus strains. The resistance rate to mupirocin was 2.3 % and plasmids carrying the mupA gene varied in size between 23 and 54.2 kb in six strains with high-level resistance as determined by Southern blot analysis. The present study showed that resistance to non-β-lactams, especially to clindamycin, is high in CA-MRSA isolates from Chinese children and that the profile of resistance is related to clonal type. This study revealed distinctive patterns of MLS(B)-resistant genes among CA S. aureus isolates.]]></abstract><cop>Reading</cop><pub>Society for General Microbiology</pub><pmid>22595913</pmid><doi>10.1099/jmm.0.042663-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of medical microbiology, 2012-09, Vol.61 (9), p.1240-1247 |
| issn | 0022-2615 1473-5644 |
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| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Anti-Bacterial Agents - pharmacology Bacteriology Biological and medical sciences Child Child, Preschool China Clindamycin - pharmacology Community-Acquired Infections - microbiology Drug Resistance, Multiple, Bacterial - genetics Fundamental and applied biological sciences. Psychology Humans Infant Infant, Newborn Infectious diseases Medical sciences Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - isolation & purification Methicillin-Resistant Staphylococcus aureus - metabolism Microbial Sensitivity Tests Microbiology Miscellaneous Mupirocin - pharmacology Sequence Analysis, DNA Staphylococcal Infections - microbiology Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Staphylococcus aureus - isolation & purification Staphylococcus aureus - metabolism |
| title | Multidrug-resistant clones of community-associated meticillin-resistant Staphylococcus aureus isolated from Chinese children and the resistance genes to clindamycin and mupirocin |
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