Rhodium(III)- and Ruthenium(II)-Catalyzed Olefination of Isoquinolones

Rhodium(III)- and Ruthenium(II)-Catalyzed Olefination of Isoquinolones

NH and N-protected isoquinolones undergo Rh(III)-catalyzed oxidative olefination at the 8-position. Complementary redox-neutral olefination of such isoquinolones using internal alkynes was achieved under ruthenium catalysis.

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Veröffentlicht in:Organic letters 2012-08, Vol.14 (16), p.4166-4169
Hauptverfasser: Zhao, Peng, Niu, Rui, Wang, Fen, Han, Keli, Li, Xingwei
Format: Artikel
Sprache:eng
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Zusammenfassung:NH and N-protected isoquinolones undergo Rh(III)-catalyzed oxidative olefination at the 8-position. Complementary redox-neutral olefination of such isoquinolones using internal alkynes was achieved under ruthenium catalysis.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol3018352