Factors related with the higher percentage of hospitalizations due to asthma amongst women: the FRIAM study

INTRODUCTIONThe reason why there is a higher hospitalization rate due to asthma exacerbations amongst women is unclear. The objective of this study is to explore the possible causes that may explain this fact.METHODSA multi-center, prospective study including asthma patients hospitalized in the pulm...

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Veröffentlicht in:Archivos de bronconeumología (English ed.) 2012-07, Vol.48 (7), p.234-239
Hauptverfasser: Melero Moreno, Carlos, López-Viña, Antolín, García-Salmones Martín, Mercedes, Cisneros Serrano, Carolina, Jareño Esteban, Javier, Ramirez Prieto, Maria Teresa
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Sprache:eng ; spa
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Zusammenfassung:INTRODUCTIONThe reason why there is a higher hospitalization rate due to asthma exacerbations amongst women is unclear. The objective of this study is to explore the possible causes that may explain this fact.METHODSA multi-center, prospective study including asthma patients hospitalized in the pulmonary medicine departments during a two-year period. By means of a questionnaire, the following data were collected: demographic characteristics and treatment compliance, anxiety-depression, hyperventilation and asthma control, both prior to and during the hospitalization.RESULTS183 patients were included, 115 (62.84%) of whom were women. The women were older (52.4 ± 18.3/43.4 ± 18.7; P=.02), were more frequently prescribed inhaled corticosteroids (63.2%/47.1%; P=.03) and had a higher rate of hyperventilation syndrome (57.3/35.9; P=.02) and a longer mean hospital stay (7.3 ± 3.4/5.9 ± 3.6; P=.02). The percentage of smokers among the women was lower (21.2%/38.8%; p=0.01) and the FEV(1) was lower at admittance (58.2% ± 15.9/67.5% ± 17.4; P=.03). In the 40 to 60-year-old age range, an association was demonstrated between being female and the 'previous hospitalizations' variable (OR, 16.1; 95% CI, 1.6-156.7); sex and obesity were also independently associated (OR, 4.8; 95% CI, 1.06-22).CONCLUSIONSIn this cohort, the rate of hospitalization for asthma was higher in women than in men. Being a woman between the ages of 40 and 60 is associated with previous hospitalizations and is a risk factor for asthma-related hospitalization. This situation could partially be explained by the hormonal changes during menopause, where polyposis and obesity are independent risk factors.
ISSN:1579-2129
DOI:10.1016/j.arbres.2012.02.008