The role of cytopathology in diagnosing HPV induced oropharyngeal lesions

HPV detection in fine needle aspirates from suspected head and neck metastasis may be useful in clinching the diagnosis of HPV related oral squamous cell carcinoma. Ascertaining the HPV status of a particular tumor on cytological specimens could be useful for prognostication as HPV‐related tumors ap...

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Veröffentlicht in:	Diagnostic cytopathology 2012-09, Vol.40 (9), p.839-843
Hauptverfasser:	Mehrotra, Ravi, Sharma, Nishant, Umudum, Haldun, Ceyhan, Koray, Rezanko, Türkan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy, Fine-Needle - methods Cell Nucleus - pathology Cell Nucleus - virology DNA, Viral - analysis DNA, Viral - genetics Head and Neck Neoplasms - pathology Head and Neck Neoplasms - virology human papilloma virus Humans Immunohistochemistry - methods in situ hybridization Neoplasms, Squamous Cell - pathology Neoplasms, Squamous Cell - virology oral cytology Oropharyngeal Neoplasms - diagnosis Oropharyngeal Neoplasms - secondary Oropharyngeal Neoplasms - virology p16 Papillomaviridae - genetics Papillomaviridae - pathogenicity polymerase chain reaction Prognosis Sensitivity and Specificity
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Zusammenfassung:	HPV detection in fine needle aspirates from suspected head and neck metastasis may be useful in clinching the diagnosis of HPV related oral squamous cell carcinoma. Ascertaining the HPV status of a particular tumor on cytological specimens could be useful for prognostication as HPV‐related tumors appear to have a better prognosis and clinical outcome. The various techniques of detection are reviewed. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
ISSN:	8755-1039 1097-0339
DOI:	10.1002/dc.21756